===================================================================== | | Secretion of Pancreatic Juice in Drops | +--------+--------------------------------------+-------- No. |Quan-|10 C.c.c| The Secretin After Incubation |10 C.c. of | tity|Secretin| with Human Gastric Juice |Secretin Exper-|of |Control +-----+------+-----+------+-----+------+Control iment|Gas- |--Begin-| | | | | | |--End of | tric| ning |Dig. |Secre-|Dig. |Secre-|Dig. |Secre-|Experi- |Juice|Experi- |Time,| tion |Time,| tion |Time,| tion | ment |Used,| ment |Hrs. |Rate |Hrs. |Rate |Hrs. |Rate | |C.c. | | | | | | | | ------+-----+--------+-----+------+-----+------+-----+------+-------- 1 | 2 | 28 |6 | 0 |4 | 0 |2 | 0 | 16 2 | 2 | 110 |2 | 7 |1-1/2| 18 |1 | 18 | 41 3 | 2 | 40 |1 | 7 | 3/4| 7 | 1/4 | 8 | 31 4 | 1 | 21 | 1/2| 11 | 1/4| 12 | 1/60| 14 | 18 5 | 8 | 20 | 1/2| 1 | 1/4| 3 | 1/60| 6 | 18 6 | 5 | 53 | 1/2| 2 | .. | .. | .. | .. | .. ------+-----+--------+-----+------+-----+------+-----+------+-------- We also tried the effect of keeping the digestive time _constant_ and varying the amount of gastric juice employed. Increasing the quantity of gastric juice used increases the quantity of secretin destroyed (Table 2). TABLE 2.--EXPERIMENT 7* Pancreatic Preparation Juice Drops 10 c.c. secretin 20 10 c.c. secretin digested with 0.5 c.c. gastric juice 15 10 c.c. secretin digested with 3 c.c. gastric juice 13 10 c.c. secretin digested with 10 c.c. gastric juice 8 * The digestive time was kept constant at fifteen minutes. (The gastric juice used had been _diluted_ with stomach washings.) The reader will observe in Table 1 that the results obtained from the control injection of secretin at the beginning of the experiment is uniformly greater than that obtained after several injections of digested secretin. In view of the established fact that equal quantities of secretin can generally be relied on to produce results,[21] one might suggest that the injections of the split products of secretin have inhibited to some degree the action of the pancreas. We can submit the data in Table 3 in support of this view, showing among other things that the action of secretin is not influenced by previous injections of inert depressor substances, though it by the injection of the cleavage products of secretin. (The various injections in the experiments were made at about fifteen-minute intervals).