==================================================================== | |Rate of Secretion| | | of Pancreatic | | | Juice in | No. of | | C.c. Per Hour |Increase Experi-| Material Fed +--------+--------+ in ment | | Three | Three | C.c. | | Hours | Hours | | | Before | After | | |Feeding |Feeding | -------+---------------------------------+--------+--------+-------- 3 |Secretin slightly acid | 5 | 11 | 6 5 |Secretin slightly alkaline | 24 | 30 | 6 4 |Secretin passed through Berkefeld| 18 | 23 | 5 1 |Secretin exposed to sun for 4 hrs| 16 | 29 | 13 2 |Extract of colon (rabbit) | 19 | 29 | 10 3 |Extract of gastric mucosa | 14 | 23 | 9 3 |Extract of muscle | 8 | 16 | 8 2 |Mixture of gelatin, peptone and | 23 | 33 | 10 | salt | | | 1 |1 per cent. peptone solution | 6 | 8 | 2 4 |0.2 per cent. hydrochloric acid | 13 | 37 | 24 3 |Milk and bread | 7 | 20 | 13 -------+---------------------------------+--------+--------+-------- It is possible by large doses of sodium bicarbonate given shortly before the administration of a preparation so to depress the stomach that it does not respond with the usual production of hydrochloric acid. Under these conditions the administration of secretin is uniformly negative, but the administration of hydrochloric acid on the contrary still serves to increase the pancreatic secretion (Table 6). TABLE 6.--SECRETIN IN EXPERIMENTAL “ACHYLIA GASTRICA”