====+================================================================= | | Rate of Secretion of Pancreatic Juice | | in C.c. Per Hour | +--------------------+------------------- Exp.| Material Fed |Continuous Secretion| Secretion After No. | | Before Feeding* | Feeding | +------+------+------+------+------+----- | |First |Second|Third |First |Second|Third ----+------------------------+------+------+------+------+------+----- 1 |} {| 8.7 | 7.5 | 6.8 | 3.0 | 1.0 | 4.8 2 |} 150 c.c. secretin {| 4.5 | 6.5 | 10.0 | 6.0 | 7.5 | 7.6 3 |} {| 15.6 | 8.1 | 16.0 | 3.9 | 4.9 | 2.9 | | | | | | | 1 |} 150 c.c. 4% HCl {| 9.8 | 7.0 | 6.0 | 65.1 | 28.0 | 7.1 2 |} (diluted to 250 c.c.){| 17.4 | 18.5 | 17.0 | 34.0 | 18.0 | 20.0 ----+------------------------+------+------+------+------+------+----- * Five gm. Na HCO₃ given at beginning of each first two hours. COMMERCIAL PREPARATIONS OF SECRETIN _Secretogen and Elixir Secretogen._--The Carnrick Company offers Secretogen[90] for use in a large number of conditions. The following indications for the use of the preparation purport to be based on clinical tests covering a period of several years: dyspepsia, and the indigestions generally, fermentative disorders, gastric catarrh, flatulence, nausea; pancreatic insufficiency, intestinal indigestion; gastric secretory deficiencies, apepsia; constipation and hepatic torpor; intestinal stasis; diarrhea; infantile diarrhea, “summer complaint,” marasmus, inanition and malnutrition; gastric atony and dilatation; cholecystitis and gallstones; nephritis, neurasthenia, cachexia and cancer; epilepsy and high blood pressure. Testimonials are presented as to results in most of these conditions. [90] Secretogen, Report of the Council on Pharmacy and Chemistry, J. A. M. A., May 1, p. 1518, 1915. A quantity of “Secretogen” and “Elixir Secretogen” was bought in the open market, and the preparations were tested on suitably prepared dogs. The tablets were ground, thoroughly macerated with the solvent used (water, normal salt solution, alcohol, or 0.4 per cent. hydrochloric acid), and filtered. If hydrochloric acid was used, the pulverized tablets were boiled with it, in the manner that secretin is made from duodenal mucosa, and the preparations neutralized previous to injection. The injections were made in from 15 to 20 c.c. of the solvent. All the operations were carried on immediately before the experiment, and as rapidly as possible, so as to avoid oxidation. The Elixir Secretogen was injected directly, without dilution.