TABLE 7.--SUMMARY OF TYPICAL EXPERIMENTS SHOWING THE ABSENCE OF SECRETIN IN “SECRETOGEN” AND “ELIXIR SECRETOGEN” EXCEPT IN OCCASIONAL TESTS WHEN ADMINISTERED IN ENORMOUS DOSES Dogs under ether anesthesia ======================================================================= | | Secretion of Pancreatic Juice in Drops, | Quantity of | Following Intravenous Injection Exp.| Secretogen +--------+---------------------------+------+-------- No.| and Elixir | | Secretogen in | | | Secretogen |Control +---------+----+-------+----+ |Control | Used* |10 C.c. |Distilled|0.4%| 70% |0.9%|Elixir|10 C.c. | |Secretin| Water |HCl |Alcohol|NaCl| |Secretin ----+-------------+--------+---------+----+-------+----+------+-------- 1 |Secretogen, | | | | | | | | 1 tablet; | 109 | 0 | 0 | 0 | 0 | 0 | 59 | Elixir, | | | | | | | | 15 c.c. | | | | | | | 1 |Secretogen, | | | | | | | | 6 tablets | ... | .. | 0 | .. | .. | .. | .. 2 |Secretogen, | | | | | | | | 3 tablets; | 16 | 0 | 0 | 0 | 0 | 1(?)| 16 | Elixir, | | | | | | | | 15 c.c. | | | | | | | 3 |Secretogen, | | | | | | | | 5 tablets | ... | .. |1(?)| .. | .. | .. | .. 4 |Secretogen, | | | | | | | | 25 tablets | 14 | .. |1(?)| .. | .. | .. | 8 5 |Secretogen, | | | | | | | | 100 tablets | 110 | .. | .. | .. | 21 | .. | 67 6 |Secretogen, | | | | | | | | 100 tablets;| 19 | .. | 5 | .. | 1 | 2(?)| 8 | Elixir, | | | | | | | | 125 c.c. | | | | | | | 7 |Elixir, | | | | | | | | 50 c.c. | ... | .. | .. | .. | .. | 1(?)| .. ----+-------------+--------+---------+----+-------+----+------+-------- * One to three tablets is (according to the label) the therapeutic dose of Secretogen; 4 to 12 c.c. the dose of Elixir Secretogen.