Its usefulness, as suggested in the advertising, when given by mouth “in the treatment of acute or chronic gastritis, gastric ulcer, or gastro-enteritis,” or the efficacy of very dilute solutions (0.2 per cent.) against dysentery, etc., is doubtful and requires substantiation by evidence. The claims that Silvol is astringent, though nonirritant and noncoagulant, that it is a “powerful germicide” or even that it is a “powerful antiseptic,” and that it may be used with advantage wherever “a silver salt is indicated,” need substantiation. There is no proof of the assertions that Silvol is “the most efficacious of silver salts”; “the most efficient antiseptic,” and “the most remarkable organic silver compound ...” As the manufacturers have not presented any evidence for their highly improbable claims, and as they have not signified any intention of making their claims agree with substantiated facts, it is recommended that Silvol be declared inadmissible to New and Nonofficial Remedies. The Council adopted the report of its referee and authorized its publication. APPENDIX The following letter from the Secretary of the Council was sent to Parke, Davis & Company, March 20, 1917. No reply to it has been received: The referee of the Council who is conducting an investigation of silver preparations asked me to inquire if you are willing to submit your evidence for the following claims which are made in your circulars for Silvol: 1. How it is possible for the solution to be astringent, and at the same time nonirritant and noncoagulant? 2. That intestinal irrigation with a Silvol solution containing 10 to 15 grains to the pint is sufficiently bactericidal to “be used in the abortive treatment of such infectious processes as dysentery, cholera infantum, and colitis.” 3. What evidence have you as to the degree of antiseptic and germicidal power of Silvol solutions? 4. What evidence have you as to the degree of antiseptic and germicidal power of 5 per cent. Silvol Ointment? A reply to the above questions and any other information in regard to Silvol will receive careful consideration.--(_From The Journal A. M. A., July 13, 1918._) KATHARMON Report of the Council on Pharmacy and Chemistry Following inquiries, the Council took up “Katharmon” for consideration and authorized publication of the following report. W. A. Puckner, Secretary.