Reason being powerless to affect the brain of the convinced, Protestants and Catholics continued their ferocious conflicts. All the efforts of their sovereigns to reconcile them were in vain. Catherine de Medicis, seeing the party of the Reformed Church increasing day by day in spite of persecution, and attracting a considerable number of nobles and magistrates, thought to disarm them by convoking at Poissy, in 1561, an assembly of bishops and pastors with the object of fusing the two doctrines. Such an enterprise indicated that the queen, despite her subtlety, knew nothing of the laws of mystic logic. Not in all history can one cite an example of a belief destroyed or reduced by means of refutation. Catherine did not even know that although toleration is with difficulty possible between individuals, it is impossible between collectivities. Her attempt failed completely. The assembled theologians hurled texts and insults at one another's heads, but no one was moved. Catherine thought to succeed better in 1562 by promulgating an edict according Protestants the right to unite in the public celebration of their cult. This tolerance, very admirable from a philosophical point of view, but not at all wise from the political standpoint, had no other result beyond exasperating both parties. In the Midi, where the Protestants were strongest, they persecuted the Catholics, sought to convert them by violence, cut their throats if they did not succeed, and sacked their cathedrals. In the regions where the Catholics were more numerous the Reformers suffered like persecutions. Such hostilities as these inevitably engendered civil war. Thus arose the so-called religious wars, which so long spilled the blood of France. The cities were ravaged, the inhabitants massacred, and the struggle rapidly assumed that special quality of ferocity peculiar to religious or political conflicts, which, at a later date, was to reappear in the wars of La Vendee. Old men, women, and children, all were exterminated. A certain Baron d'Oppede, first president of the Parliament of Aix, had already set an example by killing 3,000 persons in the space of ten days, with refinements of cruelty, and destroying three cities and twenty-two villages. Montluc, a worthy forerunner of Carrier, had the Calvinists thrown living into the wells until these were full. The Protestants were no more humane. They did not spare even the Catholic churches, and treated the tombs and statues just as the delegates of the Convention were to treat the royal tombs of Saint Denis.