About the time of Wyeth’s first expedition, there appeared in Saint Louis what had somewhat of the character of a delegation from the native tribes west of the Rocky Mountains. It consisted, as the story runs, of four or five men from the Nez Perce tribe, who, having heard of the White Man’s God and his Book, were come to ask that men be sent to teach their people of these. The story of this strange and interesting mission was taken up by the press and spread throughout the country. It gave a new impulse and a new direction to the efforts of missionary societies for the evangelization of the native tribes. One of the first fruits of this new interest in missions was the organization by the Mission Board of the Methodist Episcopal Church of a mission to the Oregon Indians. This mission, as finally constituted, consisted of the Reverend Jason Lee, as leader, and his nephew, Daniel Lee, and three lay members, Cyrus Shepard, Philipp L. Edwards, and Courtney M. Walker, five in all, a mission of men only. Sending their goods and supplies by sea to the Columbia, they joined Wyeth in the spring of 1834, and traveled with him overland, reaching Vancouver about the middle of September of that year. After personal examination of the field by the leader, it was determined that the mission should settle in the Willamette Valley, and a spot was fixed upon not far from the site of the present town of Salem, and within easy reach of a settlement already made by some retired employees of the Hudson’s Bay Company. The object of the mission was the evangelization of the Indian tribes of the valley, seemingly with little thought at first of contributing to the colonization of the country. This mission, indeed, the first among the Oregon Indians, like the trading settlements that preceded it, lacked as first constituted one essential to permanence. It did not include the family. The mistake was doubtless early seen by the missionaries themselves, but was not remedied until the arrival of the first reinforcement to the mission, more than two years later. From the coming of the first reinforcement in the spring of 1837, and the constitution thereupon of several families, the mission began to take on somewhat of the character of a permanent settlement, and with still further reinforcements a year or two later, became the nucleus of the first permanent American colony in the Willamette Valley.