By this process of investigation a series of centres for active stimulation have been discovered. These number, in the brain of the rat, six; in the brain of the rabbit, seven; of the cat, eleven; of the dog, thirteen; and of the monkey, at least, seventeen. A curious limitation to the area of experiment has been encountered here, for all the centres identified are found to cluster over the central region of the brain, and both the front and rear parts of the organ are silent, offering no response however greatly stimulated. The explanation of this silence remains a matter of doubt. It may be that these portions of the brain are concerned with movements which do not come under the observation of the operator, or that they are centres of sensibility from which no movement can naturally follow, or that they fulfil functions which can not be recognized by this mode of experiment. Uncertainty hangs over this department in the investigation. The actual results may be indicated by a few examples. At a point well forward in the brain of the dog, marked number one by Ferrier, is a centre which when stimulated leads to movement of the hind leg on the opposite side; and by exciting another portion of the brain quite contiguous, marked number four, movement of the opposite fore leg is produced. By exciting a point situated over these two and on a distinct convolution, wagging of the tail is induced. By transferring the needle to a point much lower down, towards the base of the brain, but still well forward, marked by Ferrier nine, the mouth is opened and the tongue moved, while in many cases a decided bark is emitted. These examples may suffice to indicate the class of results obtained; and similar results have been seen in all animals subjected to this test, with such variations as may be considered inevitable in view of the configuration of the animal.