minute medullated _nerve fibres_ arise."[DC] "From the observations of Lockhart Clark, Arndt, Cleland and Meynert, there can be no doubt that the pyramidal nerve cells vary in relative size and in numbers in the different layers of the gray cortex, and that the largest sized pyramidal cells lie in the third and fourth layers."[DD] "Large pyramidal cells are found in the _frontal lobe_ in considerable numbers," but it is added, "there is no difficulty in recognizing in the occipital lobe" (the back region of the brain) "a small proportion of cells quite equal in magnitude to the largest cells of the frontal lobe."[DE] From these statements, it is easy to judge what value can be attached to the conjecture that multipolar or pyramidal cells are to be regarded as "_mind-cells_." The result may be summarized thus; (1) The larger cells are invariably distinguished by the number of fibres given off, or the lines of communication they have with other parts of the tissue; (2) As to distribution of these cell-fibres appearing in the brain, it is found that as the cells themselves are in the lower strata of the gray matter, the majority of their fibres stretch downwards, the mass of the nerve fibres thus communicating with the organism; (3) These pyramidal cells are not peculiar to any part of the brain, and they do not belong to the brain alone, but are found in the gray matter of the spinal cord, and also of the sympathetic system, which provides for the action of the heart, lungs, and other vital organs. All these characteristics are adverse to the conjecture that for the larger sized cells a claim can be made assigning to them distinctively intellectual or mental functions.