The triumph of Christianity and its mystic theories meant retrogression to anatomy, as it did to all the other sciences. The popes were resolved above all things to detain humanity in ignorance; they rightly deemed a knowledge of the human organism to be a dangerous source of enlightenment as to our true nature. During the long period of thirteen centuries the writings of Galen were almost the only source of human anatomy, just as the works of Aristotle were for the whole of natural history. It was not until the sixteenth century, when the spiritual tyranny of the papacy was broken by the Reformation, and the geocentric theory, so intimately connected with papal doctrine, was destroyed by the new cosmic system of Copernicus, that the knowledge of the human frame entered upon a new period of progress. The great anatomists, Vesalius (of Brussels), and Eustachius and Fallopius (of Modena), advanced the knowledge of our bodily structure so much by their own thorough investigations that little remained for their numerous followers to do, with regard to the more obvious phenomena, except the substantiation of details. Andreas Vesalius, as courageous as he was talented and indefatigable, was the pioneer of the movement; he completed in his twenty-eighth year (1543) that great and systematic work _De humani corporis fabrica_; he gave to the whole of human anatomy a new and independent scope and a more solid foundation. On that account he was, at a later date, at Madrid--where he was physician to Charles V. and Philip II.--condemned to death by the Inquisition as a magician. He only escaped by undertaking a pilgrimage to Jerusalem; in returning he suffered shipwreck on the Isle of Zante, and died there in misery and destitution.