The presence of a grain of sand in a watch will retard its movements, if not arrest them altogether. What, then, must be the result of an accumulation of impurities in the physical system? The finely adjusted balance that is capable of weighing the thousandth part of a grain, is carefully protected under a glass cover, for even impalpable dust would clog its movements. Reflect, then, upon the amount of friction that must be perpetually going on in the human organism owing to the retention of effete matter! And since not even the most cunning product of man's handiwork can compare with the intricate mechanism of the body, the importance of eliminating the waste becomes manifest. Here, in a nutshell, lies the secret of disease. Let us now consider how the retention of waste affects the system--how the deleterious effects are produced. There are three factors at work in this process, mechanical, gaseous and absorptive, the last named being infinitely the most pernicious. We will first consider the mechanical. Nature has beautifully apportioned the space in the abdominal cavity, each part of the viscera having ample room for the performance of its special function, but any abnormal increase in size of any part of the contents of the cavity must necessarily create disturbance. Now, when the food leaves the stomach, where it has been churned into a pulpaceous mass, it passes into the duodenum or second stomach, where it receives an augmentation of liquid material from the liver and pancreas; consequently, when it reaches the small intestine, where absorption takes place, it is in a well diluted condition. During its passage through the small intestine, the nutrient portion of the ingesta is abstracted from it by the villi (small hair-like processes) with which the small intestine is thickly studded, so that at the end of its journey of about twenty-two feet (if digestion is normal) all that is of value to the organism has been appropriated--the remainder being refuse. This waste product passes into the colon, or large intestine, and should be promptly expelled. If prompt expulsion does not take place, this is what happens: The fluid portion of this semi- liquid waste is re-absorbed through the walls of the colon directly into the circulation, a percentage of the solids being deposited on the walls of the intestine. This process of accretion goes on from day to day, week to week, month to month, until it not infrequently happens that the colon becomes distended to several times its natural size. Instances are on record, where these abnormal accumulations of faecal matter in the colon have been mistaken for enlargement of the liver, and even pregnancy. A surgeon in London has a preparation of the colon measuring some twenty inches in circumference, containing three gallons of faecal matter, and even larger accumulations have been reported. The foregoing instances are, of course, exceptional ones, but it is safe to assert that seventy per cent.