Defecation, or the expulsion of waste substance from the bowel is accompanied by the contraction of the circular fibres of the said muscular coat, but when constipation has existed for any length of time, the accumulated matter adhering to the walls of the colon renders that organ partially, if not wholly rigid, hence the difficulty of evacuation; consequently, through disuse, the muscles become to a certain extent atrophied, and require stimulation to resume their natural function even after the colon has been cleansed. It is largely owing to the use of this antiseptic "tonic" that the "Cascade Treatment" has been so successful in cases of obstinate constipation, as by its use the intestine speedily regains tone and power. I unhesitatingly assert that if the colon be regularly cleansed and disinfected by this means, any bacilli or bacteria that may have obtained a lodgment in the system will be quickly destroyed and expelled--it cannot be otherwise. And once the germs of disease are destroyed and their chief breeding place kept clean by this simple process, and the re-absorption of poisonous liquid waste into the system thus prevented, Nature, the great physician, will speedily assert itself and effect a restoration to health. NOTE. If the water is not readily expelled do not attempt to force it out by straining. Instead, flatten in the abdomen by forcibly contracting the abdominal muscles. PART IV. HOW TO USE IT. Having endeavored to show the true nature of disease, the rational method of treating it, and the superiority of the "Cascade" over all previously existing methods for carrying the treatment into effect, it may be well to explain the actual manner of using the "Cascade." In the first place, the reservoir should be thoroughly washed out with slightly warm water, to get. rid of the factory dust. At one time it was the practice to cleanse them all thoroughly before fitting them, but purchasers got the impression that they had been used by other persons, so it was decided to abandon that practice and send them out with the dust of the factory in them, in proof of their newness.