ophthalmic medicines upon a recent shell until it becomes soft and of a tawny colour. Erasistratus says that Diagoras condemned the use of it in diseases of the ears and eyes, as inducing dimness of sight and coma. And Andreas says, that if it had not been adulterated those that rubbed it in would have been deprived of sight by it. But Mnesidemus says, that the only proper use of it is by the smell, as thus disposing to sleep, for that otherwise it proved injurious; but these statements are false, as is proved by experience; for the operation of the medicine is attested by its effects. He concludes by describing the modes by which opium and meconium were prepared, but it will be sufficient for our purpose to state that his description of the former of these is exactly the same as the method now commonly practised. See Kæmpfer (Amæn. Exost. 643), and Pereira (M. M. 1274.) The meconium was the expressed juice of the leaves and head, and is not now in use. Dioscorides states that it is much weaker than the other. (iv, 65.) Pliny’s description of the opium and meconium is obviously taken from Dioscorides, or both these authors must have copied from some preceding authority. He thus describes the meconium: “cum capita ipsa et folia decoquuntur, succus meconium vocatur, multum opio ignavior.” (H. N. xx, 76.) Opium it is certain was freely used by the Empirics, and accordingly it will be found that it is a very common ingredient in the prescriptions of Scribonius Largus, and Marcellus the Empiric. The latter gives several formulæ for collyria, in which opium occurs, and he is at pains to state that it is the concrete and not the expressed juice which must be used. (De Medicamentis, viii.) He also prescribes it internally for pains of the kidneys (xxvi), as an enema in colic (xxix), and in many other cases. Galen would appear to have had very sound opinions respecting the use of opium in the treatment of diseases. He professes, indeed, never to have had recourse to it when he could help it. (De Comp. med. sec. loc. iii); but yet he prescribes it in cæliac and certain stomach affections (ibid, viii), and even in intense pains of the eyes (Meth. Med. ii), although in general he condemns the application of it in collyria. (Meth. Med. iii; and De Comp. m. s. l. ii.) He often mentions that castor counteracts the prejudicial effects of opium. (De med. sec. loc. iii, and viii.) Of all kinds of opium he pronounces the Theban to be the best. (De Antid. i.) Avicenna, besides treating of opium as a poison, and giving the general properties of poppy, under that head, has a very interesting chapter on opium in his Mat. Med. He defines opium to be the juice of the black Egyptian poppy dried in the sun. He says it proves fatal if given in a larger dose than two drachms; but the proper dose he states to be the size of a tare. He states in parenthesis that opium is also formed from the juice of the wild lettuce (lactucarium?). He calls it narcotic and sedative of all