A rheumatic cooly was subjected to the influence of half a grain of hemp resin. In two hours the old gentleman became talkative and musical, told several stories, and sang songs to a circle of highly delighted auditors, ate the dinners of two persons, subscribed for him in the ward, and finally fell soundly asleep, and so continued until the following morning. At noon he was perfectly free from headache, or any unpleasant sequel; at his request, the medicine was repeated, and he was indulged with it for a few days, and then discharged. A medical pupil took about a quarter of a grain of the resin in the form of tincture. A shout of loud and prolonged laughter ushered in the symptoms, and a state of catalepsy occurred for two or three minutes. He then enacted the part of a Rajah giving orders to his courtiers; he could recognize none of his fellow students or acquaintances—all to his mind seemed as altered as his own condition; he spoke of many years having passed since his student’s days, described his teachers and friends with a piquancy which a dramatist would envy, detailed the adventures of an imaginary series of years, his travels, his attainment of wealth and power. He entered on discussions on religious, scientific, and political subjects, with astonishing eloquence, and disclosed an extent of knowledge, reading, and a ready apposite wit, which those who knew him best were altogether unprepared for. For three hours and upwards he maintained the character he at first assumed, and with a degree of ease and dignity perfectly becoming his high situation. This scene terminated nearly as abruptly as it commenced, and no headache, sickness, or other unpleasant symptoms followed the excess. Without detailing instances in which its virtues as a medicinal agent are set forth, or naming cases of hydrophobia in which it was given and failed, or of tetanus in which it was resorted to with success, we can scarce forbear noticing the fact, that to an infant only 60 days old, 130 drops of the tincture had to be given to produce narcotism, whilst 10 drops produced those effects in the student above named, who believed himself an important Rajah. The most recent information we have of the effects of haschisch is supplied by Professor K. D. Schroff. It relates to a kind called “Birmingi,” the laughter producer (“macht keif”) obtained from Bucharest. This preparation was in the form of tablets, hard and difficult to break, externally almost black and smooth, with but a slight smell. The taste was neither bitter nor aromatic, but rather insipid. On prolonged mastication, the very tough mass became gradually pappy, and eventually dissolved in the saliva, leaving a crumbling solid substance. It produced irritation in the throat, when chewed for a long time.