Dr. Heinrich took ten grains of this preparation in May, 1859, at about half-past five in the afternoon. He chewed this quantity for about an hour, during which it gradually dissolved and was swallowed; only the insoluble residue, about two grains, was spit out. Irritation of the throat, and slight nausea, succeeded. The attempt to smoke a cigar in the open air had to be given up on account of dryness and roughness in the throat. Dr. H. walked into town, and looked at the print-shops without perceiving any change in himself. At the end of an hour and a half, about seven o’clock, he met an acquaintance, to whom he talked all kinds of nonsensical trash, and made the most foolish comparisons; henceforth, everything he looked at seemed to him ridiculous. This condition of excitement lasted about twenty minutes, during which his face and eyes grew redder and redder. Suddenly a great degree of sadness came over him; everything was too narrow for him—he acquired a disturbed appearance, and became pale. His sadness increased to a feeling of anxiety, accompanied by the sensation as if his blood was flowing in a boiling state up to his head; the feeling as if his body was raised aloft, and as if he was about to fly up, was particularly characteristic. His anxiety and weakness overcame him to such a degree, that he was obliged to collect all the power of his will, and his companion had to seize him firmly under the arm, in order to bring him on, which was done in all haste, as he feared a new attack, and wished, if possible, to reach a place where he could be taken care of; but in the course of three minutes, while he was still walking, the attack set in with increased violence.