The frequent association between alcoholism and certain forms of insanity is sometimes taken as evidence of a racial effect. Here again we find the question really left open when we appeal to facts taken in large numbers. In a few cases it seems to have been demonstrated that saturation of the bodily tissues with alcohol affects directly the structure of the germ cells formed at that time, and that this effect is seen in physical and mental disturbances of the offspring derived from such germ cells, and thus becomes hereditary or racial. But these results, like those mentioned above, need confirmation. The impairment of the child _in utero_ through maternal overindulgence in alcohol would not necessarily denote any corresponding germinal (i. e., racial) effect. It is often the case that alcoholic excess, like other forms of excess, may be an indication of a lack of complete mental balance or sanity, sure to have become expressed in some form. The lack of balance in the offspring of such persons is a simple case of heredity and not the result of the parental use of alcohol. The alcoholism of the parent was a result, an indication, and not a cause. There may be instances of the direct action of external conditions upon the germ, and in a very true sense the body is a part of the external environment of the germ, but to say that such an action has been demonstrated for alcohol is premature. It should be easily possible to get real evidence upon this and similar questions. But at present it is safest to leave the whole question of the racial effects of alcohol entirely open pending more and better evidence. To summarize, then, we may say that the evidence for an inherited effect of the misuse of alcohol is not as clear as one might wish; it may be true. There is the greatest need for the careful scientific investigation of this and allied problems. Much of the evidence here is not of the kind that can be used to prove things--it consists largely of the demonstration of the fact of association rather than of causation. In order to show that a changed environment has produced a change in the innate characters of the organisms affected it must be demonstrated that the organismal change continues to be inherited after the environment has again become what it was originally, and as yet this has not been done. Indeed when tested in this way it is found that a permanently heritable alteration can thus be produced only rarely and by environmental changes of the most profound character.