In 1767 had Cowpox. In 1791 was inoculated with Smallpox without effect. Had also acted as nurse to Smallpox patients without catching the disease. V.--MRS. H----, Gentlewoman. Had Cowpox when very young, contracted by handling dairy utensils. Was subsequently exposed to Smallpox, “where it was scarcely possible for her to have escaped;” and in 1778 was inoculated with Smallpox by Jenner without effect. * * * * * At this point, I would draw attention to the ages of the persons set forth in these Cases: they were past middle life when the susceptibility to Smallpox was either low or extinct. The reason given by Jenner for their production was that he “wished to show that the change produced in the constitution by Cowpox is not affected by time”--a claim which vaccinators at this day surrender, insisting on the necessity of re-vaccination to maintain “the benign influence;” but apart from that consideration, there was nothing extraordinary in resistance to inoculated Smallpox. Without the intervention of Cowpox, inoculators were constantly meeting patients who would not “take,” even with repeated attempts, and especially among elderly people; and some who obstinately resisted inoculated Smallpox, subsequently contracted the disease in the ordinary way. So much Jenner himself allowed, saying-- There are many who from some peculiarity in habit resist the common effects of variolous matter inserted into the skin, and in consequence are haunted through life with the distressing idea of being insecure from subsequent infection. (P. 60.) Yet he was pleased to refer this well recognised resistance to variolation in those who had had Cowpox to Cowpox, allowing nothing for habit of body! VI.--SARAH WYNNE, Dairymaid. In 1796 had Cowpox in May, and “in so violent a degree, that she was confined to her bed, and rendered incapable for several days of pursuing her ordinary vocation.” On 28th March, 1797, she was inoculated with Smallpox by Jenner without effect. Under this Case Jenner observes, that “among our dairy farmers those who have had Smallpox either escape Cowpox, or are disposed to have it slightly; and as soon as the complaint shows itself among cattle, assistants are procured, if possible, who are thus rendered less susceptible of it, otherwise the business of the farm could scarcely go forward.” At the farm where Sarah Wynne was employed, all had had Smallpox except Sarah, and all save Sarah, escaped. VII.--WILLIAM RODWAY, Dairyman. In 1796 had Cowpox. In 1797 was inoculated with Smallpox by Jenner without effect.