3rd. Have any bad effects occurred in your experience in consequence of Vaccination? and if so, what are they? 4th. Is the practice of Vaccination increasing or decreasing in your neighbourhood? if decreasing, to what cause do you impute it? To the 1100 circulars only 426 replies were received. Why nearly two-thirds of the members kept silent when at the outset they were converted in multitude to Vaccination, was left unexplained. The replies were thus summarised by the Board on 17th March, 1807-- The number of persons stated in such letters to have been vaccinated, is 164,381. The number of cases in which Smallpox had followed Vaccination is 56. The Board think it proper to remark under this head, that, in the enumeration of cases in which Smallpox has succeeded Vaccination, they have included none but those in which the subject was vaccinated by the surgeon reporting the facts. The bad consequences which have arisen from Vaccination are-- 66 cases of eruption of the skin, and 24 of inflammation of the arm, whereof 3 proved fatal. Vaccination, in the greater number of Counties from which reports have been received, appears to be increasing: in the Metropolis it is on the decrease. The principal reasons assigned for the decrease are-- Imperfect Vaccination, Instances of Smallpox after Vaccination, Supposed bad consequences, Publications against the practice, Popular prejudices. The report of the Edinburgh College of Physicians disowned acquaintance with Vaccination, the practice being entirely in the hands of surgeons and other practitioners-- With a view, however, to publish their conviction of the immense benefits which have been, and which will in future be derived to the world, from Inoculation for the Cowpox, they had spontaneously and unanimously elected Dr. Jenner an honorary Fellow of their College, a mark of distinction which they very rarely confer, and which they confine almost exclusively to Foreign Physicians of the first eminence. The report of the College of Surgeons, dated 3rd March, 1807, left nothing for the Jennerians to desire. The Edinburgh surgeons were satisfied from their own experience that Vaccination constituted a permanent security from Smallpox, and they had observed no ill consequences from the practice. Vaccination commenced in Edinburgh in 1801, and was now so general in the city-- That for two or three years past, Smallpox has been reckoned rather a rare occurrence, even among the lower order of the inhabitants, _unless in some particular quarters about twelve months ago_. Among the higher ranks of the inhabitants the disease is unknown. Rare, unless in some quarters about a year ago! We turn to the report of the Edinburgh Dispensary for 1805, and there we read-- The loathsome disease has unfortunately been very prevalent in several quarters of the city.