When she was very young God took from her, first her mother, and then her father, and she remained an orphan under the charge of her grandmother, the Condesa de Luna, and after her death under that of her brother, who fulfilled his duties well and sought a wealthy marriage for her by arrangement, after the custom of the time, between the two families. The bridegroom chosen was Luis Méndez Quijada, Manuel de Figueredo and Mendoza, Colonel of the Spanish infantry, Steward to the Emperor Charles V, and Lord of Villagarcia, Villanueva de los Caballeros, and Santofimia, and also of Villamayor in the region of Campos, in right of his mother. The pair did not know each other; Doña Magdalena lived in Toro with her brother, and Luis Quijada followed the Emperor in his wars and journeys, having been his favourite for twenty years. The marriage articles were arranged in Valladolid on the 29th of February, 1549. D. Diego Tabera, Councillor to H.M. and the Inquisition, represented the bride, and the bridegroom was represented by his uncle, the Archbishop of Santiago, D. Pedro Manuel, and by the illustrious gentleman D. Gómez Manrique and D. Pedro Laso de Castilla, Steward to Prince Maximilian, Archduke of Austria. By these articles the Marqués de la Mota promised to give his sister a fortune of ten million maravedises, paid by 5000 ducats in money, 2000 in jewels, and the rest by an annuity, adding this clause: "Besides the ten 'cuentos' she is to have clothes and apparel and furniture and ornaments for the house, which she has or will have up to the day of the wedding, estimated by two persons on oath." The bridegroom promised for his part tapestry worth 4000 ducats and to endow her with the towns of Villanueva de los Caballeros and Santafimia, which for this purpose he pledged. The marriage was authorised by the Emperor. Luis Quijada sent from Brussels, where he was then living, full powers to his brother Álvaro de Mendoza to marry Doña Magdalena in his name, and this he did in Valladolid on the 27th of November, 1549, adding this clause to the document in his own hand: "And in the name of the said D. Luis Quijada, my brother, for him and as if he himself were present and as a gentleman of noble birth, I do homage once, twice, three times in the presence and under the authority of D. Bernardo de Acuña, Commander of the Order of Santiago, gentleman of noble birth, who through me, and in the said name received him, taking my hand in his according to the law of Spain, that the said Lord Luis Quijada, my brother, shall have and keep and fulfil and pay all that is said and is contained in this writing in good faith, and without deception and without adding or taking away under the penalties which befall and are incurred by gentlemen of noble birth who do not keep their word, faith and homage."