The Toxicity of Caffein: An experimental study on different species of animalsSalant, William
Science
The Toxicity of Caffein: An experimental study on different species of animals
Salant, William
Caffeine -- Physiological effect
-----------+---------+------------
Date. | Weight. | Treatment.
-----------+---------+------------
| _Grams._| _cc._
Aug. 17 | 1,260 | 12.5
Aug. 18 | 1,340 | 13.0
Aug. 19 | 1,335 | 13.0
Aug. 20 | 1,300 | 13.0
Aug. 21 | 1,325 | 13.0
Aug. 22(1) | |
Aug. 23 | 1,205 | 12.0
Aug. 24 | 1,200 | 12.0
Aug. 25 | 1,285 | 12.5
Aug. 26 | 1,185 | 12.0
Aug. 27 | 1,255 | 12.5
Aug. 28(1) | |
Aug. 29 | 1,115 | 11.0
Aug. 30 | 1,135 | 11.5
Aug. 31 | 1,175 | 12.0
Sept. 1 | 1,050 | 10.5
Sept. 2 | 900 | 9.0
-----------+---------+------------
(1) Not fed.
September 3, found dead. _Autopsy_: Stomach and small intestines showed
numerous hemorrhagic spots; thick coating of mucus surrounded the
contents of the stomach; bladder was greatly distended with urine; the
other organs were apparently normal.
_Rabbit 388._ _Belgian male._
Given 1 cc of 1 per cent caffein for each 100 grams, through stomach
tube.
-----------+---------+------------
Date. | Weight. | Treatment.
-----------+---------+------------
| _Grams._| _cc._
Aug. 17 | 1,080 | 10.0
Aug. 18 | 1,115 | 11.0
Aug. 19 | 1,150 | 11.5
Aug. 20 | 1,130 | 11.5
Aug. 21 | 1,120 | 11.0
Aug. 22(1) | |
Aug. 23 | 1,020 | 10.0
Aug. 24 | 985 | 10.0
Aug. 25 | 960 | 9.5
Aug. 26 | 900 | 9.0
Aug. 27 | 875 | 9.0
Aug. 28(1) | |
-----------+---------+------------
(1) Not fed.
August 29, found dead 9 a. m. _Autopsy_: Heart and lungs normal; liver
and kidneys engorged; stomach normal; intestines showed a catarrhal
inflammation, though not severe; spleen normal; walls of colon somewhat
injected.
_Rabbit 391._ _Belgian._
Given 1 cc of 1 per cent caffein to each 100 grams through stomach tube.
-----------+--------+-----------
Date. | Weight.|Treatment.
-----------+--------+-----------
|_Grams._| _cc._
Aug. 17 | 940 | 9.5
Aug. 18 | 950 | 9.5
Aug. 19 | 955 | 9.5
Aug. 20 | 935 | 9.5
Aug. 21 | 945 | 9.5
Aug. 22(1)| |
Aug. 23 | 835 | 8.5
Aug. 24 | 805 | 8.0
Aug. 25 | 800 | 8.0
Aug. 26 | 765 | 7.5
Aug. 27(2)| 690 | 7.0
Aug. 28(1)| |
Aug. 29 | 565 | 5.5
-----------+--------+-----------
(1) Not fed.
(2) Poor condition.
August 30, found dead 9 a. m. _Autopsy_: Heart injected; lungs normal;
liver affected slightly with coccidiidea; stomach normal in appearance;
small intestines normal, but colon considerably inflamed; kidneys
slightly engorged; other organs normal.
_Rabbit 402._ _Black female._
Given 1 cc of 1 per cent caffein to each 100 grams.
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