The Toxicity of Caffein: An experimental study on different species of animalsSalant, William
Science
The Toxicity of Caffein: An experimental study on different species of animals
Salant, William
Caffeine -- Physiological effect
------------+---------+-----------
Date. | Weight. | Treatment.
------------+---------+-----------
| _Grams._| _cc._
Aug. 20 | 1,640 | 16.5
Aug. 21 | 1,640 | 16.5
Aug. 22(1) | |
Aug. 23 | 1,490 | 15.0
Aug. 24 | 1,515 | 15.0
Aug. 25 | 1,475 | 15.0
Aug. 26 | 1,390 | 14.0
Aug. 27 | 1,330 | 13.5
Aug. 28(1) | |
Aug. 29 | 1,130 | 11.5
Aug. 30 | 1,055 | 10.5
------------+---------+-----------
(1) Not fed.
August 31: Found dead at 3 p. m. _Autopsy_: Extensive gastroenteritis;
liver enlarged and congested; spleen slightly congested; peritoneum
thickened and congested; other organs normal.
_Rabbit 884._ _Black, female._
Given 1 cc of 1 per cent caffein for each 100 grams through stomach
tube.
------------+---------+-----------
Date. | Weight. | Treatment.
------------+---------+-----------
| _Grams._| _cc._
Aug. 16 | 1,195 | 12.0
Aug. 17 | 1,205 | 12.0
Aug. 18 | 1,140 | 11.5
Aug. 19 | 1,180 | 12.0
Aug. 20 | 1,145 | 11.5
Aug. 21 | 1,145 | 11.5
Aug. 22(1) | |
Aug. 23 | 1,005 | 10.0
Aug. 24 | 1,035 | 10.5
Aug. 25 | 990 | 10.0
Aug. 26 | 960 | 9.5
Aug. 27 | 955 | 9.5
Aug. 28(1) | |
Aug. 29 | 870 | 9.0
Aug. 30(2) | 850 | 8.5
Aug. 31 | 810 | 8.0
Sept. 1 | 740 | 7.5
------------+---------+-----------
(1) Not fed.
(2) Poor condition, mucus from rectum.
September 2: Found dead at 9 a. m. _Autopsy_: The mucosa of stomach
showed numerous hemorrhagic spots; the first portion of the small
intestines was slightly congested; the other organs were apparently
normal in appearance.
_Rabbit 383._ _Belgian, female._
Given 1 cc of 1 per cent caffein for each 100 grams through stomach
tube.
-----------+---------+------------
Date. | Weight. | Treatment.
-----------+---------+------------
| _Grams._| _cc._
Aug. 16 | 995 | 10.0
Aug. 17 | 1,005 | 10.0
Aug. 18 | 990 | 10.0
Aug. 19 | 895 | 9.0
Aug. 20 | 945 | 9.5
Aug. 21 | 965 | 9.5
Aug. 22(1) | |
Aug. 23 | 875 | 9.0
Aug. 24 | 855 | 8.5
Aug. 25 | 850 | 8.5
Aug. 26 | 785 | 8.0
Aug. 27 | 710 | 7.0
-----------+---------+------------
(1) Not fed.
August 28: Found dead at 9 a. m. _Autopsy_: Lungs, heart, and spleen
apparently normal; liver infected with coccidia; stomach apparently
normal; walls of small intestines injected; colon marked congestion and
hemorrhagic; kidneys hemorrhagic.
_Rabbit 387._ _Belgian male._
Given 1 cc of 1 per cent caffein for each 100 grams through stomach
tube.
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