December 8: 11.40 a. m., received 30 cc 2 per cent caffein by subcutaneous injection (50 mg per kilo); 1 p. m., depressed in spirit, hind legs seemed somewhat stiff, no desire for regular food, site of injection inflamed. December 9: 10.50 a. m., received 30 cc 2 per cent caffein by subcutaneous injection (50 mg per kilo); 2.30 p. m., had vomited, no desire for regular food. December 10: Inflammation of site of injection, and swelling very pronounced; 2 p. m., received 0.5975 gram caffein, or 50 mg per kilo, with 30 grams of meat, refused regular food. December 11, 12: Received 0.5975 gram caffein by mouth, no symptoms except refusal of regular food, feces fetid. December 13-22: Put on meat diet exclusively, high temperature, no caffein, weight 10 kilos, appetite good, feces fetid. December 22: 12 a. m., weight 11 kilos, received 1.2 grams caffein by mouth (0.109 gram per kilo); 4 p. m., no symptoms. December 23: 11.30 a. m., received 1.375 grams caffein (0.125 gram per kilo) had vomited food of the day before, but could notice no caffein or capsules in vomit; 4.30 p. m., no symptoms, seemed in good spirits, appetite good, had no meat to feed with, so was given low nitrogen feed, of which he ate about one-fourth. December 24: 9 a. m., found dead, stiff, and cold. The most striking effect of caffein in this dog is the increased intestinal putrefaction. The feces were still fetid 10 days after the administration of caffein was stopped. _Autopsy, dog 28_: Stomach partially filled with an undigested food mass; mucosa showed severe inflammation; small intestines presented a hemorrhagic enteritis along whole extent; large intestine also exhibited mild inflammation; liver was engorged; spleen appeared normal; kidneys slightly congested in cortical portion; other organs appeared normal. _Dog 24. White and tan male_: Was put on low protein diet six weeks before experiments with caffein were begun. The initial dose of 50 mg per kilo was then administered on eight consecutive days. The only symptoms observed during this period of caffein administration were those of intestinal putrefaction. Fetid feces were noticed already after the first dose of caffein was injected. When the second dose of 75 mg of caffein was repeated, mild symptoms appeared, but none have been observed even with increased amounts of caffein. One-third nitrogen diet. Received daily 0.269 gram nitrogen per kilo (88.269 calories per kilo). October 26: Weight 11.15 kilos. Food consisted of 5 grams cracker meal per kilo; meat, 3 grams per kilo; lard, 2 grams per kilo; tapioca, 10.69 grams per kilo. Kept in a cold, damp room with poor ventilation until November 20. November 3: Weight, 11 kilos. November 10: Weight, 10.75 kilos. November 20: Weight, 10.55 kilos; changed to a warm room, with bedding and good ventilation. November 29: Weight, 10.85 kilos. December 1: Put into a cage.