December 6: Weight, 10.90 kilos; 11.25 a. m., received 28 cc 2 per cent caffein subcutaneously in side, below the shoulders, area washed with alcohol and ether, approximately 50 mg per kilo administered, no symptoms. December 7: 10.15 a. m., received 28 cc 2 per cent caffein injected subcutaneously; feces soft and very fetid; 1 p. m., depressed in spirit, eyes dull. December 9: 10.45 a. m., received 25 cc 2 per cent caffein solution subcutaneously, feces still fetid, site of injection inflamed and swollen, no other symptoms. December 10: Inflammation of area of injection more pronounced; 2 p. m., given 0.5449 gram caffein and 30 grams of meat; 4 p. m., fed, no symptoms, feces fetid. December 11: 12 a. m., given 0.5459 gram caffein and 30 grams of meat, no symptoms, feces fetid. December 12, 13: Given 0.5459 gram caffein daily, without noticing any symptoms. December 14: 12 a. m., received 0.817 gram caffein (75 mg per kilo); 2.30 p. m., restless and uncomfortable, no other symptoms. December 15: 11.30 a. m., received 0.8175 gram caffein by mouth; 2 p. m., depressed in spirit, acted as though sick, no other symptoms. December 16: Weight, 11 kilos; 11 a. m., received 0.100 gram caffein per kilo (1.100 grams) by mouth, no symptoms. December 17: Rested. December 18: 2.30 p. m., received 1.100 grams caffein by mouth; 4 p. m., no symptoms. December 19: 12 noon, received 1.100 grams caffein by mouth; 4.15 p. m., no symptoms. December 20: 2.45 p. m., given 1.375 grams caffein (0.125 gram per kilo); 3.45 p. m., vomited--one of the capsules being found intact, the other broken open; 4 p. m., given regular diet, containing 1.3757 grams caffein in capsules, ate most of this during the night, whined at intervals, coordination disturbed, appeared very sick, but exhibited no other symptoms. December 21: 9 a. m., found dead, stiff, and cold. The total amount of caffein received by dog 24 was between 10.109 and 11.484 grams. As one of the capsules vomited was intact and the other broken open, the amount was probably about 10.75 grams. The fatal dose in this case was undoubtedly less than 185 mg per kilo--somewhere between 125 and 185 mg. Autopsy showed heart in diastole; posterior lobe of right lung deeply congested; liver engorged; gall cyst filled; spleen appeared normal; stomach well filled with semifluid mass; pyloric portion of stomach exhibited a severe inflammation of mucosa; mucosa of duodenum greatly inflamed and showed hemorrhagic areas and catarrhal exudate; remainder of small intestine also exhibited mild inflammation; kidneys deeply engorged, mesentery injected.