The Toxicity of Caffein: An experimental study on different species of animalsSalant, William
Science
The Toxicity of Caffein: An experimental study on different species of animals
Salant, William
Caffeine -- Physiological effect
August 3: Found dead 9 a. m. _Autopsy_: Thoracic viscera apparently
normal; stomach immensely distended and filled with a white, cheesy
mass and some fluid; round worms plentiful in stomach and small
intestine; mucosa of entire intestine congested; contents of lower
intestine congested; liver pale; spleen flabby; kidney congested.
_Dog 10. Weight, 1,650 grams._
July 26: 9.30 a. m., 29 cc of 2 per cent caffein added to 60 cc of milk
offered, but refused, and was therefore fed by mouth through stomach
tube; 10.25 a. m., no symptoms; 11.30 a. m., restlessness, extremities
stiff, post. extremities spread apart, dog shows well-marked symptoms
of caffein poisoning; 12.10 p. m., symptoms more severe, extremities
extended and spread out, is lying flat on belly so that nose touches
floor of the cage; 12.40 p. m., found dead; was alive at 12.10 p. m.
_Autopsy_: Lungs showed hemorrhagic foci in all lobes; heart apparently
normal; liver fatty; stomach and intestines filled with round worms;
spleen and kidney apparently normal.
_Dog 9. Weight, 3,000 grams._
July 25: 350 mg caffein per kilo; 5 p. m., lying down most of the
time, occasionally walks about in stall; restlessness present, but not
marked; 5.30 p. m., vomit which looked frothy and mucilaginous noticed
on the floor of the stall; no meat particles noticed in vomit, though
searched for; whines occasionally.
July 26: 9 a. m., looks well; no signs of the effect of caffein given
the day previous.
_Dog 8. Yellow female. Weight, 3,100 grams._
July 22: 10.50 a. m., received 1.1 grams of caffein in 10 grams of meat
(354 mg caffein per kilo); 3 p. m., vomited mucus; gait clumsy; refused
to eat; continually drinking water; very restless; 4 p. m., convulsions
set in at 3.55 p. m.; tonic rigidity of the posterior extremities;
profuse salivation; convulsions were both tonic and clonic in
character, and resembled those seen in rabbits in caffein intoxication;
a striking feature was the duration of the spasm, which began at 3.55
p. m. and kept up for more than two hours.
July 23: Found dead at 9 a. m.
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