The Toxicity of Caffein: An experimental study on different species of animalsSalant, William
Science
The Toxicity of Caffein: An experimental study on different species of animals
Salant, William
Caffeine -- Physiological effect
August 19: Found dead 9 a. m. _Autopsy_: Lungs severely congested and
partially hepatized; liver was engorged; other organs appeared normal.
_Rabbit 382._ _Belgian female._
On August 17 weighed 1,035 grams; received 1 cc of 1 per cent caffein
for each 100 grams; 10 cc of 1 per cent caffein given in all.
August 18: Found dead 9 a. m. _Autopsy_: Lungs congested and hepatized;
liver engorged; stomach showed numerous petechial hemorrhages on
mucosa; kidneys slightly congested; intestines appeared normal.
_Rabbit 385._ _Belgian female._
Given 1 cc of 1 per cent caffein for each 100 grams, through stomach
tube.
--------+--------+----------
Date. | Weight.|Treatment.
--------+--------+----------
|_Grams._| _cc._
Aug. 17| 780 | 8.0
Aug. 18| 760 | 7.5
Aug. 19| 755 | 7.5
Aug. 20| 715 | 7.0
Aug. 21| 700 | 7.0
--------+--------+----------
August 22: Found dead 9 a. m. _Autopsy_: Lungs exhibited pneumonic
lesions, with inflammation of adjacent pleura; a fibro-plastic exudate
present around lung; liver showed a coccidial infestation; stomach
distended with ingesta; mucous membrane characterized by a catarrhal
inflammation; contents of small intestine liquid in nature and bile
stained; large intestine somewhat impacted; liver and kidneys seemingly
normal.
_Rabbit 404._ _White male._
Given 1 cc 1 per cent caffein for each 100 grams.
------------+---------+------------
Date. | Weight. | Treatment.
------------+---------+------------
|_Grams._ | _cc._
Aug. 20 | 1,465 | 14.5
Aug. 21 | 1,475 | 14.5
Aug. 22(1) | |
Aug. 23 | 1,475 | 14.5
Aug. 24 | 1,400 | 14.0
Aug. 25(2) | 1,405 | 14.0
Aug. 26 | 1,415 | 14.0
Aug. 27 | 1,400 | 14.0
Aug. 28(1) | |
Aug. 29 | 1,310 | 13.0
Aug. 30 | 1,320 | 13.0
Aug. 31 | 1,330 | 13.5
Sept. 1 | 1,335 | 13.5
Sept. 2 | 1,315 | 13.0
Sept. 3 | 1,350 | 13.5
Sept. 4 | 1,335 | 13.5
Sept. 5 | 1,350 | 13.5
Sept. 6 | 1,380 | 14.0
Sept. 7 | 1,375 | 14.0
Sept. 8 | 1,325 | 13.0
------------+---------+------------
(1) Not fed.
(2) Reflexes.
September 9: Found dead 9 a. m. _Autopsy_: Both lungs showed extensive
pneumonia, with adhesions to pleura; pleuritis and pericarditis very
marked; large amount of fibrous exudate in pleural cavity; pyloric end
of stomach slightly congested; liver congested; other organs normal.
_Rabbit 393._ _Belgian._
Given 1 cc of 1 per cent caffein to each 100 grams, through stomach
tube.
Public-domain text, read in full here on John Shaqi.
Reviews
Reviews
No reviews yet
Be the first to share your thoughts on this work.
Elsewhere in the archive
Join the Discussion
Join the discussion
Sign in to leave a comment or review.
Sign InorCreate an account