The Toxicity of Caffein: An experimental study on different species of animalsSalant, William
Science
The Toxicity of Caffein: An experimental study on different species of animals
Salant, William
Caffeine -- Physiological effect
------------+---------+------------
Date. | Weight. | Treatment.
------------+---------+------------
| _Grams._| _cc._
Aug. 17 | 950 | 9.5
Aug. 18 | 910 | 9.0
Aug. 19 | 895 | 9.0
Aug. 20 | 910 | 9.0
Aug. 21 | 905 | 9.0
Aug. 22(1) | |
Aug. 23 | 825 | 8.0
Aug. 24 | 870 | 8.5
Aug. 25 | 835 | 8.5
Aug. 26 | 780 | 8.0
Aug. 27 | 765 | 7.5
Aug. 28(1) | |
Aug. 29 | 710 |
Aug. 30(2) | |
Aug. 31(1) | |
------------+---------+------------
(1) Not fed.
(2) Condition very poor; not fed.
September 1: Found dead. _Autopsy_: Lungs congested and adhering to the
pleura; extensive inflammation of pleura; liver slightly enlarged and
congested; mucosa of stomach and small intestines slightly congested;
other organs normal.
_Rabbit 390._ _Belgian, male._
Given 1 cc of 1 per cent caffein to each 100 grams through stomach tube.
------------+---------+------------
Date. | Weight. | Treatment.
------------+---------+------------
| _Grams._| _cc._
Aug. 17 | 1,490 | 15.0
Aug. 18 | 1,370 | 14.0
Aug. 19 | 1,365 | 13.5
Aug. 20 | 1,340 | 13.5
Aug. 21 | 1,265 | 12.5
Aug. 22(1) | |
Aug. 23 | 1,120 | 11.0
------------+---------+------------
(1) Not fed.
August 24: Found dead 9 a. m. _Autopsy_: Heart and lungs appeared
normal; abdominal viscera showed no apparent pathologic change other
than coccidial infection of the liver and fullness of the blood
vessels.
_Rabbit 392._ _Maltese, female._
Given 1 cc of 1 per cent caffein to each 100 grams through stomach tube.
------------+---------+-----------
Date. | Weight. | Treatment.
------------+---------+-----------
| _Grams._| _cc._
Aug. 17 | 1,265 | 12.5
Aug. 18 | 1,275 | 12.5
Aug. 19 | 1,240 | 12.5
Aug. 20 | 1,220 | 12.0
Aug. 21 | 1,245 | 12.5
Aug. 22(1) | |
Aug. 23 | 1,180 | 12.0
Aug. 24 | 1,190 | 12.0
Aug. 25 | 1,155 | 11.5
Aug. 26 | 1,140 | 11.5
Aug. 27 | 1,140 | 11.5
Aug. 28(1) | |
Aug. 29 | 1,115 | 11.0
Aug. 30 | 1,080 | 11.0
Aug. 31 | 1,020 | 10.0
Sept. 1 | 995 | 10.0
Sept. 2 | 930 | 9.0
------------+---------+-----------
(1) Not fed.
Died at 3 p. m. September 2. _Autopsy_: The stomach and small
intestines showed numerous small hemorrhagic spots; a thick coating of
mucus surrounded the contents of the stomach; the other organs were
apparently normal.
_Rabbit 403._ _Black._
Given 1 cc of 1 per cent caffein for each 100 grams.
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