Everybody noticed the mutual affection between "uncle" and "nephew," which gave clear indication of a nearer relationship. Clement's word was Alessandro's law, and, when the cousins fell out, as they did many times a day, the interference of their uncle brought peace, but for Ippolito dissatisfaction, as he was usually ruled to be in the wrong. This boyish rivalry led to more considerable emulation and the proprieties of the Papal palace were rudely shaken by the quarrels and the struggles of the cousins. They were parted and removed each to a remote portion of the palace, with separate suites of attendants, and their only meetings took place in the private apartments of the Pope, and rarely. Thus Ippolito and Alessandro entered upon their teens with no judicious, kindly, or formative influences around them. It was said that each boy threw in the other's face the fact of his illegitimacy, which fawning dependants had revealed to them. Their environment and associates were most undesirable, and nothing was done to instil and encourage sentiments of honour, self-control, truthfulness, and charity. Their initiation into the hypocrisies of spiritual life and ecclesiastical duty produced distaste and contempt for religious exercises. There was yet another protégée of Clement's left upon the world of mutability and chance--an orphan child, the only issue of Lorenzo, Duke of Urbino and his wife Maddalena, daughter of Jean de la Tour d'Auvergne et de Bourbon. Married in 1518, the delicate young mother died in childbirth the following year, leaving her sweet little baby girl, Caterina, to the care of her broken-hearted husband. The future Queen of France was placed with the foundling nuns of the convent of Santa Lucia in the Via San Gallo. Thence she was removed to the convent of Santa Caterina di Siena, back to the nuns of Santa Lucia once more, and then handed over to the charge of the noble convent of S. Annunziata delle Murate until 1525, when her aunt, Madonna Clarice de' Medici, wife of Messer Filippo negli Strozzi, was constituted her guardian and instructress. Right well the new _governante_ carried out the instructions of Clement, and she only relinquished her charge when the Pope commanded the young girl, just eleven years old, to Rome. Apartments were provided for her and her suite in the Palazzo Medici, where Madonna Lucrezia, Lorenzo il Magnifico's daughter, and wife of Giacomo de' Salviati, was appointed her protectress.