The first forms of life were one-celled—simple, jelly-like dots of almost homogeneous plasm—the _protozoa_. These primitive organisms were the common grandparents of all beings. From them evolved, through infinite travail and suffering, all of the orders, families, species, and varieties of animals that to-day live on the earth, and all those that have in the past lived and passed away. By the multiplication and specialisation of cells, and the formation of cell aggregates, the sponges, celenterates, and flat worms were developed from the protozoa.[1] The connecting links between the one-celled and the many-celled animals consist of a series of colonial forms of increasing size and complexity, some of which may be found in every roadside ditch and pool, while others are extinct. The development of these many-celled organisms (metazoa) from one-celled organisms was a perfectly natural process, a process which takes place in the initial evolutions of every embryo. There is no more mystery about it than there is about any other act of association. All association is simply a matter of ‘business.’ Many-celled organisms are colonies, or societies, of more or less closely co-operating one-celled organisms, and they have come into existence in obedience to the same laws of economy and advantage as have those more modern societies of metazoa known as nations, communities, and states, the organised bodies of men, ants, and millionaires. The sponges are the lowest of the many-celled animals. They consist of irregular masses of loosely associated cells, hopelessly anchored to the sea-floor. They represent the social instinct in embryo. The cells are but slightly specialised, and each cell leads a more or less independent existence. The sponge stands at about that stage of social integration and intelligence represented by those stupendous porifera which cover continents and constitute the ‘social organisms’ of the civilised world. The nutritive system of sponges consists of countless pores opening from the surface into a common canal within, through which ever-waving cilia urge the alimental waters. In the celenterates the cells arrange themselves in the form of a cup with one large opening into and from the vase-like stomach. The unsegmented worms are flat and sac-like, with bilateral symmetry and the power to move about, but not tubular, as are the true worms. They are bloodless, like the celenterates and sponges.