that the food mixture fails to accomplish. Daniels and Byfield have recently confirmed the effect of increased "B" in infant growth. Cramer has suggested in a paper published recently in _The American Journal of Physiology_ that the fatty tissue about the suprarenals may be a depository of vitamine and that in the absence of vitamine this tissue loses its supply and that this is the explanation of lessened activity of that gland in certain metabolic disturbances. This idea tends to support the idea that vitamines are gland stimulants or hormones and the word food hormone has been suggested to describe them on that account. A few years ago Calkins and Eddy tried to determine the effect of the vitamine on the single cell by use of the paramecium but the results of the experiments failed to show a vitamine requirement on the part of these animals. McDougall has recently suggested that the vitamines produce their effect on yeast cells by increasing hydration. Unfortunately nearly all stimuli which produce growth are accompanied by hydration effects and it is difficult to feel that this is a specific vitamine effect although without denying the possibility. Dutcher has tried to show that vitamines have a relation to oxidation effects. He observed that the issues of polyneuritic birds showed a marked reduction in catalase and that this catalase was restorable by curing the birds with vitamine. The main difficulty lies in the conflexity of factors that function between cause and effect. [Illustration: FIG. 8. THE EFFECT OF VITAMINE B ON A MARASMIC INFANT _1_. On the twentieth day the patient developed a cough. _2_. On the twenty-first day the cereal was reduced from three times a day to twice a day. The patient cried during the night. _3_. On the twenty- second day the stools showed free starch. _4_. On the twenty-third day an anal abscess was opened. The stools continued to show free starch until the twenty-fifth day. _5_. On the twenty-fifth day the stools showed soluble starch but no free starch. _6_. On the twenty-seventh day the appetite was good and there was no starch. _7_. From the twenty-eighth to the forty-third day no starch was observed in the stools. _8_. On the thirty-first day the patient developed a cough. _9_. From the forty-ninth day to the time of discharge three tablespoonsful of orange juice were given daily. _10_. On the seventy-third day the patient developed a bronchitis and mustard paste was applied every four hours up to the eighty-fourth day. _V1_ = From the twenty-first day to the forty-third day the patient received each day 2 grams of Lloyd powder, activated with pancreatic vitamin. The powder was administered by mixing 1 gram. with each cereal feeding. The result was 20 ounces gain in twenty-two days, a normal growth.