“If we now try to explain the striking phenomena which so invariably accompany our experiments, it is quite impossible not to conclude from the outset that they are the result of the closing of the coronary artery. It is quite true that less frequent beating of the heart, and even irregularities of the pulse, may occur spontaneously, and certainly without ligature of the coronary artery. Any one who has made frequent experiments on dogs in which the pressure of the blood has been noted down during a long period, knows very well that intermittent pulsation, and even greater irregularities, are not unfrequent occurrences in narcotised and bound or curarised animals--irregularities which disappear or re-appear, as the case may be. But the sudden ceasing of the diastolic beating of the heart may also occasionally be observed in dogs whose coronary arteries have not been touched. However, this only happens spontaneously (according to our experience) in dogs which have already been used for a long succession of experiments, which have resulted in the natural alteration of the action of the heart, and in whom the arterial pressure has been lowered to a great degree, more especially when for hours the thorax has been open, and experiments have been made on the greater vessels, or the functions of the heart, or on pericardial pressure, etc.… However, there can be no question that the manipulations of the heart, which are inseparable from our experiments, should be the cause of this result.” … (Here M. Cohnheim makes this naif remark), “Many observers have expressed surprise at the amount of pain which a dog’s heart can bear!”--“_Ueber die Folgen der Krauzarterienver schliessung für das Herz_,” Virchow’s _Archiv._, Vol. 85, 1881, pp. 520-21. “The great majority of our experiments were made on dogs under curari with artificial respiration, but several were under morphia; with rabbits there is no particular difficulty in dispensing with all narcotics.”--Virchow’s _Archiv._ =Colasanti, Joseph.= M.D. Univ. Rome. Author of “Researches on Uric Acid,” Atti della R. Accademia di Roma, 1881; “Action of Oxygenated Water in Poisoning Dogs;” “Zur Kenntniss der Physiologischen Wirkungen des Curaregiftes,” Pflüger’s _Archiv._, Vol. XVI., pp. 157-8, &c.