“In addition to these experiments, we have made some observations clinically. To eighteen adults--fourteen men and four women--we ordered ten grains of the pure nitrite of sodium in an ounce of water, and of these seventeen declared that they were unable to take it.… One man, a burly, strong fellow, suffering from a little rheumatism only, said that after taking the first dose he ‘felt giddy,’ as if he would ‘go off insensible.’ His lips, face, and hands turned blue, and he had to lie down for an hour and a half before he dared move. His heart fluttered, and he suffered from throbbing pains in the head. _He was urged to take another dose, but declined on the ground that he had a wife and family._ Another patient had to sit down for an hour after the dose, and said that it ‘took all his strength away.’ He, too, seemed to think that the medicine did not agree with him.… The women appear to have suffered more than the men.… One woman said that ten minutes after taking the first dose--she did not try a second--she felt a trembling sensation all over her, and suddenly fell on the floor. Whilst lying there, she perspired profusely, her face and head seemed swollen and throbbed violently, until she thought they would burst.… Another woman said she thought she would have died after taking a dose; it threw her into a violent perspiration, and in less than five minutes her lips turned quite black and throbbed for hours; it upset her so much that she was afraid she would never get over it. The only one of the fourteen patients _who made no complaint_ after taking ten grains was powerfully affected by fifteen.… The effect on these patients was so unpleasant that it was deemed unadvisable to increase the dose.”--Drs. Ringer and Murrell in _Lancet_, Nov. 3, 1883. _Held a License for Vivisection at University College, London, Physiological Theatre in 1878._ =Nasse, Hermann.= Prof. Med. Fac., Univ. Marburg. Author of “Ueber die Ausfluss geschwindigkeit des Blutes aus den Halsgefässen der Hunde und über die modification derselben durch Infusion von Kochsalz in die Gefässe,” Pflüger’s Archiv, Vol. XXII., p. 513.