Man, because of the fundamental disharmonies in his constitution, does not develop normally. The earlier phases of his development are passed through with little trouble; but after maturity greater or lesser abnormality begins, and ends in old age and death that are premature and pathological. Is not the goal of existence the accomplishment of a complete and physiological cycle in which occurs a normal old age, ending in the loss of the instinct of life and the appearance of the instinct of death? But before attaining the normal end, coming after the appearance of the instinct of death, a normal life must be lived; a life filled all through with the feeling that comes from the accomplishment of function. Science has been able to tell us that man, the descendant of animals, has good and evil qualities in his nature, and that his life is made unhappy by the evil qualities. But the constitution of man is not immutable, and perhaps it may be changed for the better. Morality should be based not on human nature in its existing condition, but on ideal human nature, as it may be in the future. Before all things, it is necessary to try to amend the evolution of human life, that is to say, to transform its disharmonies into harmonies. This task can be undertaken only by science, and to science the opportunity of accomplishing it must be given. Before it is possible to reach the goal mankind must be persuaded that science is all-powerful and that the deeply-rooted existing superstitions are pernicious. It will be necessary to reform many customs and many institutions that now seem to rest on enduring foundations. The abandonment of much that is habitual, and a revolution in the mode of education, will require long and painful effort. But the conviction that science alone is able to redress the disharmonies of the human constitution will lead directly to the improvement of education and to the solidarity of mankind. The Prolongation of Life Professor Metchnikoff's volume, on "The Prolongation of Life: Studies in Optimistic Philosophy," was published in 1907, and is in some respects the most original of his works. In it he carries much further the arguments and the studies to which he made brief allusion in "The Nature of Man," and he lays down certain principles for the prolongation of life which have been put into practice by a large number of people during the last two or three years, and are steadily gaining more attention. Sour milk as an article of diet appears to have a peculiar value in arresting the supposed senile changes which are largely due to auto-intoxication or self-poisoning. _I.--Senile Debility_