When we study old age in man and the lower animals, we observe certain features common to both. But often among vertebrates there are found animals whose bodies withstand the ravages of time much better than that of man. I think it a fair inference that senility, that precocious senescence which is one of the greatest sorrows of humanity, is not so profoundly seated in the constitution of the higher animals as has generally been supposed. The first facts which we must accept are that human beings who reach extreme old age may preserve their mental qualities, notwithstanding serious physical decay, and that certain of the higher animals can resist the influence of time much longer than is the case with man under present conditions. Many theories have been advanced regarding the cause of senility. It is certain that many parts of the body continue to thrive and grow even in old age, as, for instance, the nails and hair. But I believe that I have proved that in many parts of the body, especially the higher elements, such as nervous and muscular cells, there is a destruction due to the activity of the white cells of the blood. I have shown also that the blanching of the hair in old age is due to the activity of these white cells, which destroy the hair pigment. Progressive muscular debility is an accompaniment of old age; physical work is seldom given to men over sixty years of age, as it is notorious that they are less capable of it. Their muscular movements are feebler, and soon bring on fatigue; their actions are slow and painful. Even old men whose mental vigour is unimpaired admit their muscular weakness. The physical correlate of this condition is an actual atrophy of the muscles, and has for long been known to observers. I have found that the cause of this atrophy is the consumption of the muscle fibres by what I call phagocytes, or eating cells, a certain kind of white blood cells. In the case of certain diseases we find symptoms, which look like precocious senility, due to the poison of the disease. It is no mere analogy to suppose that human senescence is the result of a slow but chronic poisoning of the organism. Such poisons, if not completely destroyed or got rid of, weaken the tissues, the functions of which become altered or enfeebled in which the latter have the advantage. But we must make further studies before we can answer the question whether our senescence can be ameliorated.