The duration of the life of animals varies within very wide limits. As a general rule, small animals do not live so long as large ones, but there is no absolute relation between size and longevity, since parrots, ravens, and geese live much longer than many mammals, and than some much larger birds. Buffon long ago argued that the total duration of life bore some definite relation to the length of the period of growth, but further inquiry shows that such a relation cannot be established. Nevertheless, there is something intrinsic in each kind of animal which sets a definite limit to the length of years it can attain. The purely physiological conditions which determine this limit leave room for a considerable amount of variation in longevity. Duration of life, therefore, is a character which can be influenced by the environment. The duration of life in mammals is relatively shorter than in birds, and in the so-called cold-blooded vertebrates. No indication as to the cause of this difference can be found elsewhere than in the organs of digestion. Mammals are the only group of vertebrate animals in which the large intestine is much developed. This part of the alimentary canal is not important, for it fulfils no notable digestive function. On the other hand, it accommodates among the intestinal flora many microbes which damage health by poisoning the body with their products. Among the intestinal flora there are many microbes which are inoffensive, but others are known to have pernicious properties, and auto-intoxication, or self-poisoning, is the cause of the ill-health which may be traced to their activity. It is indubitable that the intestinal microbes or their poisons may reach the system generally, and bring harm to it. I infer from the facts that the more the digestive tract is charged with microbes, the more it is a source of harm capable of shortening life. As the large intestine not only is that part of the digestive tube most richly charged with microbes, but is relatively more capacious in mammals than in any other vertebrates, it is a just inference that the duration of life of mammals has been notably shortened as the result of chronic poisoning from an abundant intestinal flora.