MONTICELLO, February 14, 1812. Thomas Jefferson presents his compliments to Dr. Wheaton, and his thanks for the address he was so kind as to enclose him on the advancement in Medicine. Having little confidence in the theories of that art, which change in their fashion with the ladies' caps and gowns, he has much in the facts it has established by observation. The experience of physicians has proved that in certain forms of disease, certain substances will restore order to the human system; and he doubts not that continued observation will enlarge the catalogue, and give relief to our posterity in cases wherein we are without it. The extirpation of the small pox by vaccination, is an encouraging proof that the condition of man is susceptible of amelioration, although we are not able to fix its extent. He salutes Dr. Wheaton with esteem and respect. TO MR. CHARLES CHRISTIAN. MONTICELLO, March 21, 1812. SIR,--I have duly received your favor of the 10th inst. proposing to me to join in a contribution for the support of the family of the late Mr. Cheetham of New York. Private charities, as well as contributions to public purposes in proportion to every one's circumstances, are certainly among the duties we owe to society, and I have never felt a wish to withdraw from my portion of them. The general relation in which I, some time since, stood to the citizens of all our States, drew on me such multitudes of these applications as exceeded all resource. Nor have they much abated since my retirement to the limited duties of a private citizen, and the more limited resources of a private fortune. They have obliged me to lay down as a law of conduct for myself, to restrain my contributions for public institutions to the circle of my own State, and for private charities to that which is under my own observation; and these calls I find more than sufficient for everything I can spare. Nor was there anything in the case of the late Mr. Cheetham, which could claim with me to be taken out of a general rule. On these considerations I must decline the contribution you propose, not doubting that the efforts of the family, aided by those who stand in the relation to them of neighbors and friends, in so great a mart for industry as they are placed in, will save them from all danger of want or suffering. With this apology for returning the paper sent me, unsubscribed, be pleased to accept the tender of my respect. TO MR. VANDER KEMP. MONTICELLO, March 22, 1812.