We allude to the flushing of the face, which is caused by paralysis of the cervical branch of the sympathetic. This symptom usually occurs some time before the conspicuous manifestation of the ordinary signs of intoxication, which result from paralysis of the cerebrum. Of these signs the most prominent is the weakening of the ordinary power of self-control. The ruling faculty of judgment is suspended, volition becomes less steady, and imagination, no longer guided by the higher faculties, runs riot in such a way as to appear to be stimulated. But it is not stimulated; it is simply let loose. There is no stimulation in drunkenness; there is only disorganization. One acquired or organic power of the mind no longer holds the others in check. Hence the uncalled-for friendliness, the fitful anger, the extravagant or misplaced generosity, the ludicrous dignity, the disgusting amorousness, or the garrulous vanity, of the drunken man. Wine is said to exhibit a man as he really is, with the conventionalities of society laid aside. This is only half true, but it suggests the true statement. Wine exhibits a man as he is when the organized effects of ancestral and contemporary civilization upon his character are temporarily obliterated. We need no better illustration of the truth that drunkenness is not stimulation but paralysis of the cerebrum, than the order in which, under the influence of alcohol, the powers of the mind become progressively suspended. As a general rule those are first suspended which are the most recent products of civilization, and which have consequently been developed by inheritance through the least number of generations. These are of course the mind's highest organic acquisitions. The sense of responsibility, for instance, is a product of a highly complicated state of civilization, and, when fully developed, is perhaps chief among the moral acquirements which distinguish the civilized man from the savage. In progressing intoxication, the feeling of responsibility is the first to be put in abeyance. A man need be but slightly tipsy in order to become quite careless as to the consequences of his actions.[3] On the other hand, those qualities of the mind are the last to be overcome, which are the earliest inheritance of savagery, and which the civilized man possesses in common with savages and beasts. Then the animal nature of the man, no longer restrained by his higher faculties, manifests itself with a violence which causes it to seem abnormally stimulated in vigour. And in the stage immediately preceding stupor, it sometimes happens that the pupils are contracted,[4] and the whites of the eyes enlarged, giving to the face a horrible brute-like expression.