When introduced into the stomach of dogs, M. Barthez found that twenty drops on a full stomach had no particular effect; that thirty drops occasioned vomiting, and temporary acceleration of the pulse and breathing; and that from forty to sixty drops on an empty stomach brought on violent vomiting, sneezing, cough, dilated pupil and prostration, succeeded in a few hours by languor without any other symptom, and by death in four or five days. In the dead body he remarked numerous little ulcers of the villous coat, some of which had an ash-gray appearance at the bottom, while others were covered with a black slough, easily removed by friction. When the gullet was tied to prevent vomiting, less doses proved more quickly fatal. He likewise observed that the matter vomited in these experiments, even a few minutes after the administration of the poison, had no appearance or odour of bromine; whence it is reasonable to conclude, that, as in the instance of iodine, a chemical change takes place with the aid of certain vital operations, so that the bromine becomes hydrobromic acid.—The experiments of Dr. Butske assign to it more activity as a poison than those now related. For he found that a dog died in a day from taking only five grains dissolved in two ounces of water; and the symptoms were laborious breathing, loud cries, and convulsions. In the dead body he found the stomach internally chequered with bloody extravasation, and filled with bloody mucus, the duodenal mucous membrane universally injected, but the rest of the alimentary canal in a healthy state.—Dr. Glover remarked in such cases, besides the usual symptoms of an irritant action on the stomach, coryza, sneezing, salivation and difficult breathing. Sixty minims killed a cat in seventeen minutes, two fluid drachms a dog in five hours and a half, ten grains a rabbit in five minutes. A dog twice got twenty grains in solution and recovered, but died after a third dose of the same amount. Another got twenty grains in solution every two or three days for a month without injury. In some of these experiments hydrobromic acid was detected in the blood and urine.