Another, somewhat similar to the preceding, has been related by M. Lachèse of Angers. Two people took about half a grain in soup twice a day for two days, and were attacked with the usual primary symptoms. One of them died in ten weeks, gradually worn out, but without any particular nervous affection. The other was seized with convulsions, and afterwards with almost complete palsy of the limbs.[665]—A well-marked case of the same nature has been noticed by Professor Bernt. It was the case formerly alluded to as arising from an over-dose of the arseniate of potass. The paralytic affection consisted in the loss of sensation and of the power of motion in the hands, and of the loss of motion in the feet, with contraction of the knee-joints. The issue of the case is not mentioned.[666]—Dr. Falconer observes in his essay on Palsy, that he had repeatedly witnessed local palsy after poisoning with arsenic, and alludes to one instance in which the hands only were paralysed, and to two others in which the palsy spread gradually from the fingers upwards till the whole arms were affected.[667]—On the whole, then, local palsy is the most frequent of the secondary effects of arsenic. It is sometimes very obstinate, as the cases related by Dehaen and Murray will show. But it even appears to be sometimes incurable. For in the German Ephemerides there is related the case of a cook, who after suffering from the usual inflammatory symptoms, was attacked with perfect palsy of the limbs, and had not any use of them during the rest of her life, which was not a short one.[668] Occasionally, instead of being palsied, the limbs are rigidly bent and cannot be extended.[669] They were contracted, as well as palsied in the case noticed by Bernt. The last nervous affection to be mentioned is mania. The only instance I have hitherto found of that disease arising from arsenic is related by Amatus Lusitanus. He has not recorded the particulars of the case, but merely observes that the individual became so outrageously mad as to burst his fetters and jump out of the window of his apartment.[670] According to Zacchias, Amatus was not very scrupulous in his adherence to fact in recording cases.