Often there is melancholia, great depression, and not infrequently complete prostration of the nervous system. The digestion may be disturbed, producing constipation, diarrhoea, dyspepsia, loss of appetite, offensive breath, biliousness, etc. Most marked changes are certainly taking place in the whole system, and it is but natural that every part of the body should be profoundly impressed. =Not Expensive Treatment.=--I cannot urge too strongly upon my readers the necessity of their taking Lydia E. Pinkham's Vegetable Compound all through these remarkable changes. It is not a great expense to take this Vegetable Compound in moderate doses four times a day for weeks, or even months, during these changes. =A Critical Time.=--If this period of life be passed over in safety, then there may be years and years of robust health remaining; while if it be not attended to properly, the remainder of the life may be one prolonged day of agony. Even when persons have suffered during all their menstrual life, they can now have perhaps a score or more of years of complete relief if they properly care for themselves during this change. =Keep Under Its Influence.=--Lydia E. Pinkham's Vegetable Compound is a great tonic in itself, bracing up the whole nervous system, aiding digestion, and causing all the forces of the body to act more in accord with nature. Then it has a special influence over the uterus and ovaries; indeed, so marked is its power to correct disease that all the trying days of the "change of life" may be passed over in perfect safety, if only the system be continuously kept under its influence. =May Be Made Easy and Natural.=--Women who have been dreading this change, and who have been made to look upon it as something horrible to pass through, may now lay all such anxiety aside, for Mrs. Pinkham long ago solved the problem of making this time of life as healthy and natural as any other. It is not claiming too much to say that if women everywhere will only take Lydia E. Pinkham's Vegetable Compound through this trying time, they will come out of it feeling better in every way than they have felt for many years. =If you do not understand your ailments, write to Mrs. Pinkham, Lynn, Mass. Her advice is free and always helpful. Such letters are strictly confidential and answered with the help of women only.= CHAPTER X. PREGNANCY, ITS SYMPTOMS, DISEASES, ETC. =Sometimes Difficult to Tell.=--Even the most skilled physicians sometimes make mistakes in stating that pregnancy exists when it does not. =The First Sign.=--The most valuable and striking sign of pregnancy is the cessation of the monthly periods; yet even this is not always reliable. Sometimes menstruation continues for three or four months, especially during the first pregnancy, although this is exceedingly rare. As a rule, to which there is hardly an exception, if menstruation ceases in a married woman who has previously been regular, she is, in all probability, pregnant.