FRANCES READ, aged 14, daughter of ---- Read, 71, Fetter Lane, and one of the scholars at the Blind School, Queen Square. Her mother said that she took her daughter to an Ophthalmic Institution until she was tired. No good was effected. The parents of this case were unable to say when the blindness first developed itself. She has always been able to see a little with the right eye. I was first consulted in this case in July, 1842, when the right eye appeared to have some vision. The pupil acted under a strong light, but very sluggishly. She could observe objects very indistinctly with the left eye. The prussic acid was employed almost daily, for three months, to both eyes. The right eye recovered so that she can now thread her needle. She is also learning to read. Upon the pupil of the left eye the prussic acid does not appear to have the least effect. As a general rule, I have found that when prussic acid does not dilate the eye, in amaurosis, much good is not to be expected from its use. In such cases I am inclined to believe that the disease is caused by pressure upon the optic nerve. It is my intention to persevere in the application of the vapour to the left eye, with the view of ascertaining whether the sight may not be restored. I do not despair of success. CASE 14. _Congenital Amaurosis._ GEORGE PRITCHARD, aged 7 years, son of Edward Pritchard, cab-driver, Black Bull Yard, Gray's Inn Lane, and one of the scholars at the Blind School, Queen Square. This patient has been totally blind from birth. His case has been examined by almost all the eminent oculists of London, and has been taken to several hospitals; but all the medical men, without one exception, stated that they would not prescribe for him, as they could do nothing for him. He was brought to me in May, 1840, at which time the eye appeared more than half sunk in each orbit, and the pupil, when exposed to the action of strong light, was fixed and immoveable. In fact, he had not the slightest perception of light. Two drops of castor oil were put into his eye daily, for the space of three months, before the pupil manifested a disposition to act. At each successive month there was a visible change in the size of the eye. When he left me, in Dec., 1840, he was not able to discern more than light from darkness. He has visited me since the month of April, 1842, and has had, once or twice a week, the vapour of the prussic acid applied to his eye. He is now so improved that he is beginning to distinguish one object from another, and the eye is assuming a healthy appearance. From the progress that this boy has made the last two months, I think it probable that the medicine may ultimately effect much greater good. The following letter was forwarded to me by H. Newnham, Esq., for the purpose of publication:-- "January 24th, 1843.