Venoms: Venomous Animals and Antivenomous Serum-therapeuticsCalmette, A. (Albert)
Science
Venoms: Venomous Animals and Antivenomous Serum-therapeutics
Calmette, A. (Albert)
Antitoxins; Poisonous snakes; Toxins; Venom
On the other hand, these venoms possess, as I have already stated,
very interesting _kinasic_ properties, which have been pointed out
by Delezenne.[62] They consist in the fact that while venom alone
is incapable of digesting cooked albumin, we have only to add to a
pancreatic juice, in itself devoid of effect upon albumin, a trace of
venom, to see this albumin immediately become digested.
_Lachesis_-venom is especially active in this respect. In Delezenne’s
experiments it was generally sufficient to add to 1 c.c. of inactive
pancreatic juice, 0·5 to 1 c.c. of a 1 in 1,000 solution, that is 0·5
to 1 milligramme of venom, to obtain the digestion of a cube of albumin
weighing 0·5 gramme in the space of from ten to twelve hours. Much
weaker doses, ⅕, ⅒, sometimes even 1/80 of a milligramme still gave the
same result, with this sole difference that digestion took twenty-four,
forty-eight, and even seventy-two hours to become complete.
_Cobra_-venom was found to be a little less active than the foregoing,
but still its action was usually evident enough when it was employed in
a dose of 0·5 milligramme or even 0·1 milligramme. As for the venom of
_Vipera berus_, it was often necessary to employ it in doses from five
to ten times stronger in order to obtain the same result.
Delezenne has ascertained, on the other hand, that these venoms
entirely lose their kinasic power when they are subjected to ebullition
for fifteen minutes.
This _kinase_ or diastase, capable of quickening the inert pancreatic
juice, must evidently be of very great utility to the reptile in
enabling it to digest its prey. Venom, therefore, is not, as has long
been believed, a purely defensive secretion; it corresponds to a
physiological necessity, like that of the intestinal or pancreatic
juice. Herein is to be found the explanation of the fact that the
non-poisonous snakes, although destitute of organs of inoculation,
possess supralabial or parotid glands which produce venomous saliva.
Experiments have been made by Ch. Féré[63] to determine the effect
upon the development of the embryo of the introduction of venom into
the albumen of the egg of the fowl. He found that 83 per cent. of
the embryos, developed in eggs intoxicated with 0·05 milligramme of
viper-venom and opened after being incubated for seventy-two hours,
exhibited various anomalies in development.
E.--ACTION OF VARIOUS DIASTASES UPON VENOMS.
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