“A girl named Hamida, aged 13, while picking cotton on October 7, 1896, at Ghizeh, near Cairo, was bitten in the left forearm by a large Egyptian cobra, which measured 3 feet in length. She cried out, and her brother and others who were working with her ran up. She was brought to hospital by the police at 7 p.m. in a state of complete collapse. She was almost cold, with upturned eyeballs and imperceptible pulse. The forearm had been bandaged with a dirty cloth, and the entire arm was covered with a thick layer of Nile mud (a favourite remedy among the Fellahîn). Above the wrist two deep punctures were clearly visible, evidently corresponding to the fangs of the reptile. The patient, whose condition seemed absolutely desperate, had no longer any reflexes; she was completely insensible; the moderately dilated pupils scarcely reacted at all to luminous impressions. Dr. Ruffer injected, with the customary antiseptic precautions, 20 c.c. of Calmette’s antivenomous serum beneath the skin of the abdomen. The child gave a groan while this was being done; this was at 7.30 p.m. At 11 o’clock at night her condition improved; the pulse was 140, and bodily heat returned; the patient replied to questions that were put to her. A second injection of 10 c.c. of serum was given in the flank. She slept for the remainder of the night, and passed her water four times under her. At 8 a.m. on October 8 she appeared to be out of danger. She took food, and dozed throughout the day. On the 9th she was convalescent. There were no complications resulting from the injection, neither eruptions nor pains in the joints.” XV.-Case reported by Dr. Maclaud, of Konakry (French Guinea). “At 7.30 p.m., on June 22, 1896, there was brought to the Konakry Hospital a native soldier, named Demba, who had just been bitten by a snake. This man, who was employed in the bakery, was stacking firewood, when he felt an extremely acute pain in the left foot; simultaneously he saw a large snake making off; he succeeded in killing it, and found it to be a black Naja. After having applied a stout ligature to the limb, the injured man hastened to the hospital, where, immediately afterwards, he fell into a condition verging on coma. The body was bathed with cold sweat; the temperature was subnormal; the pulse, which was small and thready, was 140. There was difficulty in breathing, and severe vomiting. At intervals the patient was aroused by spasms, and excruciating pains in the injured limb, which exhibited considerable œdema above and below the ligature. Tendency to asphyxia. I washed the wounds with 1 per cent. solution of permanganate of potash, and injected a dose of antivenomous serum into the subcutaneous cellular tissue of the left flank. In view of the severity of the symptoms I gave two other injections of serum, an injection of 3 c.c., followed by one of 2 c.c. The patient dozed all night. Next day the general symptoms had entirely disappeared. Two days later Demba returned to duty.”