With health somewhat impaired and with family cares increasing, David Dodge now turned from teaching to trade. First it was as a clerk in Norwich, then as a partner in a general store, then as head of various dry goods establishments in Hartford and other Connecticut towns, always and everywhere successful. In 1805 Messrs. S. and H. Higginson of Boston, cousins of his wife, a firm of high standing and large capital, made him a proposition to enter into a copartnership with a view to establishing an extensive importing and jobbing store in the city of New York; and he accepted the proposition, going to New York the next year to take charge of the concern in that city. He took a store in Pearl Street, and the year afterwards the family took possession of the house connected with the store, still reserving the house in Hartford as a retreat in case of yellow fever in New York. From this time until his death, April 23, 1852, New York was, with occasional interruptions, his home and the center of his varied and ever enlarging activities. Just before the outbreak of the war with England his partners became bankrupt through losses in extensive shipping of American produce to Europe. "Bonaparte sprung his trap upon more than a million dollars of their property." Mr. Dodge now established cotton factories in Connecticut, and later commenced anew the dry goods business in New York, his home for years alternating between New York and the Norwich neighborhood; and for the nine years following 1835 he occupied a large farm in Plainfield, New Jersey.