therapeutics we shall discover the pathways of natural curative medicine. It is not the introduction into human bodies of vegetable and mineral remedies or poisons; it is simply the introduction of correlated gland extracts from other mammals. As far as we know, the glands of the herbivora answer as well as the glands of the omnivora, but we may have to correct this view. In treating hyperpiesis, we shall come across some cases that seem to yield to thyroid treatment hardly at all, and here the trouble is often found to be chiefly, if not entirely, in intestinal absorption of deleterious products of faulty digestion; there may or may not be signs of colitis; but, as I have said before, duodenal extract freely given alters the condition rapidly in most cases. In these cases probably the absorption of these residues of defective digestion produces hyperadrenia, and the adrenal-thyroid balance is disturbed. Dr. Sajous (in his paper previously mentioned) claims that calomel in very small doses, not exceeding gr. 1/12, is a powerful activator of the thyroid secretion; he claims that so given it has been effective in checking epidemics of diphtheria. It probably acts partly as an intestinal bactericide and partly by its action on the thyroid, increasing the defensive anti-bodies in the blood. There is one other medicine that has a very decided action on some forms of raised pressure, and that is hippuric acid. This again is a natural or endogenous cure. It was introduced by the late Dr. George Oliver of Harrogate, and is chiefly used as sodium or lithium hippurate. For some time before his death Dr. Oliver was seeking for a reasonable explanation of its action, but his death unfortunately came before he had carried this through. I can give no theory, but of its effects in many cases I feel convinced, though I cannot say beforehand in which class of case it will answer. In the pre-sclerotic cases of middle life it often acts quickly and well, even better than thyroid. Again, in old age, in cases where one would expect thyroid to give the better results, it answers equally well.