Some Quaker workers were her friends in Helena, and in 1868 she went to Lauderdale, Mississippi, to help the Friends in an orphan asylum. Six weeks after her arrival the superintendent's daughter died, and the parents left to take their child back to their Indiana home to rest. Miss Moore was left in charge of the asylum. Cholera broke out. Eleven children died within one week. She stood by her post. Often, as she said, those who were well and happy when they retired, ere the daylight came were in the cold grave, for they were buried the same hour they died. Night after night the lone woman prayed to God in the dark, and at length the fury of the plague was abated. From time to time the failing health of her mother called her home, and from 1870 to 1873 she once more taught school in the vicinity of Belvidere. The first winter the school was in the country. "You can never have a Sunday School in the winter," she was told. But she did; in spite of the snow the house was crowded every Sunday; whole families came in sleighs. Even at that the real work of the missionary was still with the Negroes of the South. In her prayers and in her public addresses they were always with her; and in 1873 friends in Chicago made it possible for her to return to the work of her choice. In 1877 the Woman's Baptist Home Mission Society honored itself by giving to her its first commission. Nine years she spent in the vicinity of New Orleans. Near Leland University she found a small, one-room house. After buying a bed, a table, two chairs, and a few cooking utensils, she began housekeeping. Often she started out at six in the morning, not to return until dark. Most frequently she read the Bible to those who could not read. Sometimes she gave cheer to mothers busy over the washtub. Sometimes she would teach the children to read or to sew. Often she would write letters for those who had been separated from friends or kindred in the dark days. She wrote hundreds and hundreds of such letters; and once in a while, a very long while, came some response. Most pitiful of all the objects she found in New Orleans were the old women worn out with years of slavery. They were usually ragpickers who ate at night old scraps for which they had begged during the day. There was in the city an Old Ladies' Home; but this was not for Negroes. A house was secured and the women taken in, Miss Moore and her associates moving into the second story. Sometimes, very often, there was real need; but sometimes, too, provisions came when it was not known who sent them; money or boxes came from Northern friends who had never seen the workers; and the little Negro children in the Sunday Schools in New Orleans gave their pennies.