“I realize now that we used zone anesthesia, as the sacral region and the nose are in the same zone. At other times we have had occasion to do minor operations on cows and pigs on my experiment farm, and have noticed that, by putting a ‘twitch’ on the nose, the animals did not seem to experience any pain. “Also, before anesthesia was so well known, I remember seeing surgeons do minor operations on individuals who would take no chloroform. Almost always the patients closed their teeth, or clinched their hands on some rough substance. Then ‘they could stand anything.’ “Later I heard Dr. William H. Fitzgerald explain zone therapy. Then I realized that we have always used zone therapy, although we did not know it. “After spending a few days with Dr. Fitzgerald, I met at a dinner party, a lady who had a severe frontal headache. Obtaining her permission to try a new ‘cure’, I exerted pressure upon the thumb, first and second fingers, and within five minutes the headache had disappeared. I had similar success in treating a toothache. “I shortly afterwards called on a New York physician who had previously been one of my pupils, and asked him if he knew anything about zone therapy. He said he did not, but had read about it in some of the journals, and thought ‘it must be all imagination.’ I then held his fingers, pretending I was trying to see how much resistance there was in his muscles. Within three minutes I laid a button hook on his eyeball without his flinching. I took a stickpin from his cravat, and pushed it into his cheek, and put several pins into his face, without his feeling them. He could not bear the touch of a pin in any other zone. He called his wife, and she was horrified when she saw him so ‘stuck up.’ I withdrew the pins and sterilized his face. He is now a staunch believer in zone anesthesia. “At several of our lecture courses in Chicago and elsewhere, I had an opportunity to show these methods, and made some very interesting observations. We found that light would not contract the pupil of the eye that had been attacked through the finger zones to the same degree as the pupil of the eye that had not been so attacked.