It is peculiarly unfortunate for the cure of this disease, that not one in ten of those who contract it, are either able or willing to submit to a proper plan of regimen. The patient is willing to take medicine; but he must follow his business, and to prevent suspicions, must eat and drink like the rest of the family. This is the true source of nine-tenths, of all the mischief arising from venereal disease. I never knew the cure attended with any great difficulty or danger where the patient strictly followed the physician’s advice; but a volume would not be sufficient to point out the dreadful consequences which proceed from an opposite conduct. Schirrous testicles, ulcerous sore throats, madness, consumptions, carious bones, and a rotten progeny, are a few of the blessings derived from this source. There is a species of false reasoning, with regard to this disease, which proves fatal to many. A person of a sound constitution contracts a slight degree of the disorder. He gets well without taking any great care, or using much medicine, and hence concludes, that this will always be the case. The next time the disease occurs, though ten times more virulent, he pursues the same course, and his constitution is ruined. Indeed, the different degrees of virulence in the small-pox are not greater than in this disease, though, as the learned Sydenham observes, in some cases the most skilful physicians cannot cure, and in others the most ignorant old women cannot kill the patient in that disorder. Though a good constitution is always in favour of the patient, yet too great stress may be laid upon it. It does not appear from observation, that the most robust constitution is able to overcome the virulence of the venereal contagion, after it has got into the habit. In this case, a proper course of medicine is always indispensably necessary. Although it is impossible, on account of the different degrees of virulence, &c., to lay down fixed and certain rules, for the cure of this disease, yet the following general plan will always be found safe, and often successful, viz.: to bleed and administer gentle purges with diuretics during the inflammatory state, and, as soon as the symptoms of inflammation are abated, to administer mercury, in any form that may be most agreeable to the patient. The same medicine, assisted by the decoction of sarsaparilla, and a proper regimen, will not only secure the constitution against the further progress of a confirmed pox, but will generally perform a complete cure.