We first hear of the duke’s madness in 1509, when he and his brother-in-law, Antonio Loredano, were on board the ducal galley, then engaged in the Venetian service at Trieste. The duke was put in custody at San Michele di Murano, but was subsequently released and allowed to return to Naxos[173]. There, as we learn from two separate accounts, one sent to the Venetian authorities in Crete by the community of Naxos, the other sent to Venice by Antonio da Pesaro, Venetian governor of Andros, the duke had a return of the malady[174]. On August 15, 1510, he was more than usually affectionate to his wife, Taddea Loredano, to whom he had been married fourteen years, and who is described by one of the Venetian ambassadors as “a lady of wisdom and great talent[175].” Having inveigled the duchess to his side “by songs, kisses, and caresses,” he seized his sword and tried to slay her. The terrified woman fled, just as she was, in her nightdress, out of the ducal palace, and took refuge in the house of her aunt, Lucrezia Loredano, Lady of Nio. Thither, in the night of Saturday, August 17, her husband pursued her; he burst open the doors, and entered the bedroom, where he found the Lady of Nio and her daughter-in-law, to whom he gave three severe blows each. Meanwhile, on hearing the noise, the duchess had hidden under a wash-tub; a slave betrayed her hiding-place, and the duke struck her over the head with his sword. In the attempt to parry the blow, she seized the blade in her hands, and fell fainting on the ground, where her miserable assailant gave her a thrust in the stomach. She lived the rest of the night and the next day, while the duke fled to his garden, whence he was induced by the citizens to return to the palace. There, as he sat at meat with his son Giovanni, he heard from one of the servants that the people wished to depose him and put Giovanni in his place. In a paroxysm of rage, he seized a knife to kill his son; but his arm was held, and the lad saved himself by leaping from the balcony. The duke tried to escape to Rhodes, but he was seized, after a struggle in which he was wounded, and sent to Santorin. His son Giovanni IV was proclaimed duke, and as he could not have been more than eleven years old—his birth is spoken of as imminent[176] in May 1499—a governor of the duchy was elected in the person of Jacomo Dezia, whom we may identify with Giacomo I Gozzadini, baron of the island of Zia, who is mentioned as being present in the ducal palace at Naxos, in a document[177] of 1500, whose family had a mansion there, and who had already been governor in 1507. From Santorin, Francesco III was removed on a Venetian ship to Candia, where, as we learn from letters of August 15, 1511, he died of fever[178].