Take: Borate of soda 2 drams Fluid ex. of gelseminum 1 dram Fluid ex. of belladonna x drops Fluid ex. of buchu 1½ ounces Fluid ex. of senna 1½ ounces Distilled water 2 ounces Syrup of orange peel sufficient to make 8 ounces Mix, and take a tablespoonful or less three times a day. Wear flannel drawers and woolen hose, so as to guard against sudden changes of the weather. NEURALGIA AND NERVOUS IRRITABILITY. The bladder is often the seat of functional derangements that are characterized by a morbid sensibility and pain. The principal symptom of this disease is a frequent desire to urinate. A careful examination of the urine reveals nothing abnormal in the fluid that would point to the slightest affection of the bladder, nor are any of the symptoms that characterize inflammation present. There is no mucous sediment, but in a large proportion of cases there is an abnormal deposit of the phosphates that would point to nerve waste. There is often a similar irritability in the vaginal canal, in fact, there is such a mutual sympathy between the two, which can hardly be located in any one particular organ. Hemorrhoids and constipation are sometimes found to be the cause. In women of a nervous temperament the bladder often becomes the seat of a steady neuralgic pain. Sometimes this pain is periodical, recurring every day and about the same hour and lasting the same period. This pain is of a lancinating character, and radiates from the bladder to the neighboring organs. I have noticed these symptoms, particularly in women who had lived in malarial districts, and whose blood had become impoverished by malarial fevers, or from excessive hemorrhages due to some uterine trouble. Sexual excesses and other abuses that lower the tone of the nervous system will also develop a neuralgic condition of these parts. Persons who seek relief from this distressing complaint must first abandon their vices before they can expect alleviation from any treatment. This affection is not in itself dangerous, but the frequent recurrence of paroxysms of pain render life miserable. If the general system requires toning up, I would recommend the iron pills after Formula I, with a good liberal diet of eggs and milk. For immediate relief of the painful spasms, the sitz-bath and hot vaginal injections are of great value. And for the irritable bladder I can recommend:—— NO. VII. Take: Bromide of sodium 3 drams Fluid ex. of gelseminum 1 dram Water sufficient to make 8 ounces Mix, and take a tablespoonful three times a day.