Having thus far endeavored to shew the futility of the objection raised against our doctrine, by the consumers of this drug; let us now, in our turn, call on them to give a good reason why so much money should be expended, and so much time wasted, as are annually squandered in the various departments of raising, preparing, and consuming this plant; and to point out, if they can, in what manner a poison so deadly acts on the healthy system without producing evil consequences. To make out the case, it will be necessary for its advocates to prove one of the following positions; either, 1. That it produces no effect at all, and is therefore harmless; or, 2. That it produces a good effect, and is indispensable to the enjoyment of perfect health. As this part of the enquiry is somewhat important, and since it regards the success of our principles, we will examine these positions a little in detail, to see how they are sustained by fact and experience. If it produces no effect at all, why that universal uneasiness, amounting as we have seen in some instances almost to distraction, uniformly manifested by the consumers of this plant, when by accident they are temporarily deprived of the means of indulgence? If tobacco produces no effect, why fly to it as a solace for every woe, as a refuge from affliction and trouble, and as a hiding-place from the tempests of misfortune? It will not, it _cannot_ be doubted, that, in its power to allay the stormy agitations of mind to which we are exposed in our voyage over the tempestuous sea of life, consists the latent excellence, the _summum bonum_, of the virtues of tobacco. This sedative power will not be questioned, by those who have ever witnessed its peculiar effects. The medicinal effects of tobacco, as applied for the removal of corporeal disorders, are nearly or quite destroyed by habitual use; but with what success it is constantly resorted to, to allay anxiety of mind, let its votaries answer.